Synthesis and Characterization of Platinum(IV) Anticancer Drugs with Functionalized Aromatic Carboxylate Ligands: Influence of the Ligands on Drug Efficacies and Uptake

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State: Public
Version: Final published version
Serval ID
serval:BIB_FFFB3DDC2A1F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Synthesis and Characterization of Platinum(IV) Anticancer Drugs with Functionalized Aromatic Carboxylate Ligands: Influence of the Ligands on Drug Efficacies and Uptake
Journal
Journal of Medicinal Chemistry
Author(s)
Ang Wee Han, Pilet Sébastien, Scopelliti Rosario, Bussy François, Juillerat-Jeanneret Lucienne, Dyson Paul J.
ISSN
0022-2623
1520-4804
ISSN-L
0022-2623
Publication state
Published
Issued date
12/2005
Peer-reviewed
Oui
Volume
48
Number
25
Pages
8060-8069
Language
english
Abstract
A series of trans-platinum(IV) complexes with functionalized aromatic carboxylate ligands, cis,cis,trans-Pt(NH3)2Cl2(CO2C6H4R)2 (R = H (3), p-vinyl (4), p-methoxy (5), p-iodo (6), p-cyano (7), or o-carboxyl (8)) was synthesized and characterized by spectroscopic methods. Crystal structures of 3, 4, 7, and 8 were obtained, which revealed that their structural conformations were influenced by intramolecular H-bonding interactions. The complexes were evaluated for cellular uptake and inhibition of cell proliferation against a panel of lung, colon, and breast carcinoma cell lines. The functionalization of the aromatic carboxylate ligand was found to have a profound influence on the uptake, and hence, efficacy, of this class of complex.
Pubmed
Web of science
Create date
26/05/2008 12:00
Last modification date
20/08/2019 17:30
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