Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.

Details

Serval ID
serval:BIB_FFE9978DEEE9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.
Journal
The EMBO journal
Author(s)
Muhlethaler-Mottet A, Otten LA, Steimle V, Mach B
Publication state
Published
Issued date
05/1997
Peer-reviewed
Oui
Language
english
Abstract
The highly complex pattern of expression of major histocompatibility complex class II (MHC‐II) molecules determines both the immune repertoire during development and subsequently the triggering and the control of immune responses. These distinct functions result from cell type‐restricted expression, developmental control and either constitutive or inducible expression of MHC‐II genes. Yet, in these various situations, MHC‐II gene expression is always under the control of a unique transactivator, CIITA. Here we show that the CIITA gene is controlled by several distinct promoters, two of which direct specific constitutive expression in dendritic cells and B lymphocytes respectively, while another mediates γ‐interferon‐induced expression. Thus the cellular, temporal and functional diversity of MHC‐II expression is ultimately controlled by differential activation of different promoters of a single transactivator gene. This provides novel experimental tools to dissect compartment‐specific gain or loss of MHC‐II function in vivo.
Keywords
CIITA, MHC-II, promoter, transactivator
Pubmed
Open Access
Yes
Create date
23/03/2020 12:44
Last modification date
25/03/2020 7:26
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