Natriuresis-pressure relationship in polycystic kidney disease

Details

Serval ID
serval:BIB_FF5F76BFA24C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Natriuresis-pressure relationship in polycystic kidney disease
Journal
Journal of Hypertension
Author(s)
Schmid  M., Mann  J. F., Stein  G., Herter  M., Nussberger  J., Klingbeil  A., Ritz  E.
ISSN
0263-6352 (Print)
Publication state
Published
Issued date
03/1990
Volume
8
Number
3
Pages
277-83
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Mar
Abstract
We studied, under outpatient conditions, nine patients with autosomal dominant polycystic kidney disease who were hypertensive on their usual diet, and nine normotensive healthy probands. The subjects were examined in random order on the 7th day after equilibration on a low-sodium diet (20 mmol/day) and again on the 7th day after equilibration on the same diet but with added sodium to yield a final intake of 200 mmol/day (or vice versa). Blood pressure was monitored non-invasively for 2 h at 4-min intervals using an automatic system. In healthy probands, mean arterial pressure (MAP) was similar on the low- and the high-sodium diets (92.7 versus 91.9 mmHg). In hypertensive patients, a significant (P less than 0.02) increase in mean MAP (107.2 versus 111.2 mmHg) and in systolic blood pressure (140.6 versus 148.7 mmHg) was observed irrespective of whether the glomerular filtration rate (GFR) was normal or reduced. The natriuresis pressure curve showed an upward shift (resetting) and a positive slope (sodium sensitivity). Patients with a reduced GFR as shown by inulin clearance differed from probands and patients with a normal GFR, by showing greater proportional changes in GFR and body weight. In hypertensive patients, atrial natriuretic factor (ANF) levels were higher at baseline and showed an exaggerated response to sodium loading. Changes in angiotensin II (Ang II) or in Ang II binding sites on platelets were similar in patients and controls and changed appropriately with the sodium intake. These data show a resetting of the natriuresis-blood pressure relationship and an increased blood pressure sensitivity to sodium in hypertensive patients with adult, dominant, polycystic kidney disease.
Keywords
Adult Angiotensin II/blood Atrial Natriuretic Factor/blood *Blood Pressure/drug effects Body Weight/drug effects Female Glomerular Filtration Rate/drug effects Humans Hypertension/etiology/physiopathology Male Middle Aged *Natriuresis/drug effects Polycystic Kidney Diseases/blood/complications/*physiopathology Receptors, Angiotensin/blood Sodium, Dietary/administration & dosage/pharmacology
Pubmed
Web of science
Create date
05/03/2008 16:40
Last modification date
20/08/2019 16:29
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