Tumor antigens recognized by T lymphocytes

Details

Serval ID
serval:BIB_FF5B5CF5A462
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tumor antigens recognized by T lymphocytes
Journal
Annual Review of Immunology
Author(s)
Boon  T., Cerottini  J. C., Van den Eynde  B., van der Bruggen  P., Van Pel  A.
ISSN
0732-0582 (Print)
Publication state
Published
Issued date
1994
Volume
12
Pages
337-65
Notes
Journal Article
Review
Abstract
Transplantation experiments have demonstrated that most mouse tumors express antigens that can constitute targets for rejection responses mediated by syngeneic T lymphocytes. For human tumors, autologous cultures mixing tumor cells and blood lymphocytes or tumor-infiltrating lymphocytes have produced CD8+ and CD4+ cytolytic T cell (CTL) clones that recognize tumor cells specifically. Attempts to identify the target antigens by biochemical fractionation of tumor cells up to now have failed, with the important exception of the identification of underglycosylated mucins present on breast and pancreatic carcinomas. Gene transfection approaches have proved more successful. A gene family named MAGE codes for antigens recognized by autologous CTL on a melanoma tumor. These genes are not expressed in normal tissues except for testis. They are expressed in many tumors of several histological types. Differentiation antigens coded by genes such as tyrosinase are also recognized on human melanoma by autologous CTL. The identification of human tumor rejection antigens opens new possibilities for systematic approaches to the specific immune therapy of cancer.
Keywords
Animals Antigens, Neoplasm/chemistry/*immunology Humans Immunotherapy/methods Mucins/immunology *Neoplasm Proteins Neoplasm Transplantation/immunology Neoplasms/immunology/therapy T-Lymphocytes/*immunology
Pubmed
Web of science
Create date
28/01/2008 11:14
Last modification date
20/08/2019 16:29
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