Risk stratification and prognosis determination using (18)F-FDG PET imaging in endometrial cancer patients: a systematic review and meta-analysis.

Details

Serval ID
serval:BIB_FF597E9BC12B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Risk stratification and prognosis determination using (18)F-FDG PET imaging in endometrial cancer patients: a systematic review and meta-analysis.
Journal
Gynecologic oncology
Author(s)
Ghooshkhanei H., Treglia G., Sabouri G., Davoodi R., Sadeghi R.
ISSN
1095-6859 (Electronic)
ISSN-L
0090-8258
Publication state
Published
Issued date
03/2014
Peer-reviewed
Oui
Volume
132
Number
3
Pages
669-676
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
In the current study, we systematically searched and analyzed the available literature on the prognostic value of semi-quantitative (18)F-FDG PET imaging (SUVmax/mean) in patients with endometrial cancer and presenting the results in a meta-analytic format.
Pubmed, SCOPUS, and ISI Web of Knowledge were searched using "endometr* AND PET" as the search algorithm. All studies evaluating the (18)F-FDG PET performance in pre-operative risk stratification or its prognostic value in patients with endometrial cancer were included. Statistical pooling of diagnostic accuracy indices was performed using random effects model. Cochrane Q test and I(2) index were used for heterogeneity evaluation.
Ten studies (771 patients) were included in the systematic review. Pooled average SUVmax values in patients with risk factors [grade III, lymphovascular invasion (LVI), cervical invasion (CI), myometrial invasion (MI)≥50%] were statistically higher than those in patients without risk factors. Pooled HR of pre-operative SUVmax for disease free survival was 7.415 [2.892-19.432] (p=0.000046).
Despite higher average SUVmax in the high-risk group compared to the low-risk group of patients with endometrial cancer, the usefulness of (18)F-FDG PET SUVmax in classifying patients into pre-defined risk groups seems to be limited. However, pre-operative SUVmax of endometrial tumors seems to be an independent prognostic marker of recurrence and death. Further large multicenter studies with adequate follow-up are needed to confirm our findings.

Keywords
Endometrial Neoplasms/diagnosis, Endometrial Neoplasms/diagnostic imaging, Female, Fluorodeoxyglucose F18, Humans, Positron-Emission Tomography, Prognosis, Radiopharmaceuticals, Risk Factors, (18)F-FDG PET, Endometrial cancer, Meta-analysis, SUVmax, Systematic review
Pubmed
Web of science
Create date
20/08/2017 18:44
Last modification date
20/08/2019 16:29
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