Cryoablation and immunotherapy of cancer.

Details

Serval ID
serval:BIB_FF3698E414D7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cryoablation and immunotherapy of cancer.
Journal
Current opinion in biotechnology
Author(s)
Yakkala C., Denys A., Kandalaft L., Duran R.
ISSN
1879-0429 (Electronic)
ISSN-L
0958-1669
Publication state
Published
Issued date
20/02/2020
Peer-reviewed
Oui
Volume
65
Pages
60-64
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Cryoablation is a hypothermic modality exercised as a focal therapy for annihilating cancer lesions. Its application leaves the ablated tumor in situ, allowing multifarious tumor antigens to be available to the host's immune system. This ensues the activation of innate and adaptive immunity against the tumor antigens. Therefore, cryoablation can be employed as an in vivo vaccination tool to fortify the impact of immunotherapies. Application of checkpoint inhibitors, toll-like receptor agonists, adoptive cell therapies and epigenetic modulators has been shown to galvanize the immune system against tumors. Preliminary data demonstrate an excellent synergy between cryoablation and immunotherapies. Future endeavors should focus on tailoring cryo-immunotherapies based on the tumor's immune signature and testing alternative approaches to circumvent treatment-associated toxicities and maximize efficacy.
Pubmed
Create date
27/02/2020 16:34
Last modification date
25/07/2020 6:26
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