Reference values for plasma and urine trace elements in a Swiss population-based cohort.

Details

Serval ID
serval:BIB_FF27C8C5A176
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reference values for plasma and urine trace elements in a Swiss population-based cohort.
Journal
Clinical chemistry and laboratory medicine
Author(s)
Perrais M., Trächsel B., Lenglet S., Pruijm M., Ponte B., Vogt B., Augsburger M., Rousson V., Bochud M., Thomas A.
ISSN
1437-4331 (Electronic)
ISSN-L
1434-6621
Publication state
Published
Issued date
28/10/2024
Peer-reviewed
Oui
Volume
62
Number
11
Pages
2242-2255
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Trace elements (TEs) are ubiquitous. TE concentrations vary among individuals and countries, depending on factors such as living area, workplaces and diet. Deficit or excessive TEs concentrations have consequences on the proper functioning of human organism so their biomonitoring is important. The aim of this project was to provide reference values for TEs concentrations in the Swiss population.
The 1,078 participants to the SKiPOGH cohort included in this study were aged 18-90 years. Their 24-h urine and/or plasma samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) to determine 24 TEs concentrations: Ag, Al, As, Be, Bi, Cd, Co, Cr, Cu, Hg, I, Li, Mn, Mo, Ni, Pb, Pd, Pt, Sb, Se, Sn, Tl, V and Zn. Statistical tests were performed to evaluate the influence of covariates (sex, age, BMI, smoking) on these results. Reference intervals for the Swiss adult population were also defined.
TEs concentrations were obtained for respectively 994 and 903 persons in plasma and urine matrices. It was possible to define percentiles of interest (P50 and P95) for almost all the TEs. Differences in TEs distribution between men and women were noticed in both matrices; age was also a cofactor.
This first Swiss biomonitoring of a large TEs-panel offers reference values in plasma and in urine for the Swiss population. The results obtained in this study were generally in line with clinical recommendations and comparable to levels reported in other population-based surveys.
Keywords
Humans, Reference Values, Adult, Male, Middle Aged, Aged, Female, Trace Elements/blood, Trace Elements/urine, Trace Elements/analysis, Switzerland, Adolescent, Cohort Studies, Aged, 80 and over, Young Adult, Mass Spectrometry/standards, Biological Monitoring, human biomonitoring, inductively coupled plasma mass spectrometry (ICP-MS), plasma, reference values, trace elements, urine
Pubmed
Web of science
Create date
29/04/2024 8:53
Last modification date
01/10/2024 7:07
Usage data