Placebo effect of pacemaker implantation in obstructive hypertrophic cardiomyopathy. PIC Study Group. Pacing In Cardiomyopathy

Details

Serval ID
serval:BIB_FF1C7A5FBEB7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Placebo effect of pacemaker implantation in obstructive hypertrophic cardiomyopathy. PIC Study Group. Pacing In Cardiomyopathy
Journal
American Journal of Cardiology
Author(s)
Linde  C., Gadler  F., Kappenberger  L., Ryden  L.
ISSN
0002-9149 (Print)
Publication state
Published
Issued date
03/1999
Volume
83
Number
6
Pages
903-7
Notes
Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Abstract
This study evaluated a possible placebo effect by pacemaker implantation. The study design was a 3-month multicenter, double-blind, randomized cross-over study to compare the effects of atrioventricular (AV) synchronous pacing with an optimal AV delay to inactive pacing in patients with obstructive hypertrophic cardiomyopathy (HC). Quality of life and left ventricular (LV) outflow tract obstruction were evaluated after the first study period in 40 patients assigned to inactive pacing. Data were compared with the corresponding results among the 41 subjects assigned to a first study period of active pacing. During inactive pacing, there was a significant improvement in perceived chest pain, dyspnea, and palpitations. Moreover, LV outflow tract gradient decreased from 71 +/- 32 mm Hg to 52 +/- 34 mm Hg (p = 0.04). In patients assigned to active pacing the reduction of the gradient was significantly more pronounced (70 +/- 24 mm Hg to 33 +/- 27 mm Hg; p <0.0001). The difference in gradient reduction between the groups was highly significant (p <0.00001). In the group assigned to active pacing there was also significant improvement in perceived symptoms as well as in alertness, the ability to be self-autonomous, and strenuous physical exercise. The improvements in the latter were significantly greater in those paced actively compared with patients paced inactively, whereas the changes in perceived symptoms did not differ between groups. In conclusion, pacemaker implantation had a placebo effect on objective and subjective parameters in this group of patients with obstructive HC.
Keywords
Adult Aged Aged, 80 and over Cardiomyopathy, Hypertrophic/complications/physiopathology/psychology/*therapy Cross-Over Studies Double-Blind Method Female Humans Male Middle Aged *Pacemaker, Artificial Placebo Effect Quality of Life Ventricular Outflow Obstruction/complications/physiopathology
Pubmed
Web of science
Create date
15/02/2008 11:29
Last modification date
20/08/2019 16:29
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