To be or not to be a pro-T?

Details

Serval ID
serval:BIB_FF0ED1023CAD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
To be or not to be a pro-T?
Journal
Current Opinion in Immunology
Author(s)
Di Santo  J. P., Radtke  F., Rodewald  H. R.
ISSN
0952-7915 (Print)
Publication state
Published
Issued date
04/2000
Volume
12
Number
2
Pages
159-65
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Apr
Abstract
Recent studies have begun to unravel some of the molecular pathways that appear to control the processes of T cell determination in the earliest thymocyte precursors. In addition, the analyses of mouse mutants with an entirely alymphoid thymus have shed light on the developmental relationship of pro-T cells and thymic dendritic cells, revealing that development of thymocytes and thymic dendritic cells can be dissociated.
Keywords
Animals Calcium-Binding Proteins Cell Differentiation Cell Lineage Cytokines/physiology Dendritic Cells/cytology *Gene Expression Regulation, Developmental Helix-Loop-Helix Motifs *Hematopoiesis/genetics Hematopoietic Cell Growth Factors/physiology Hematopoietic Stem Cells/*cytology Humans Inhibitor of Differentiation Protein 1 Intercellular Signaling Peptides and Proteins Membrane Proteins/physiology Mice Radiation Chimera Receptors, Cytokine/physiology Receptors, Notch *Repressor Proteins Signal Transduction T-Lymphocyte Subsets/*cytology Thymus Gland/cytology Transcription Factors/classification/physiology Transcription, Genetic
Pubmed
Web of science
Create date
28/01/2008 11:39
Last modification date
20/08/2019 16:29
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