Multiple metastatic clones assessed by an integrative multiomics strategy in clear cell renal carcinoma: a case study.
Details
Serval ID
serval:BIB_FF02D1E9F4B0
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Multiple metastatic clones assessed by an integrative multiomics strategy in clear cell renal carcinoma: a case study.
Journal
Journal of clinical pathology
ISSN
1472-4146 (Electronic)
ISSN-L
0021-9746
Publication state
Published
Issued date
06/2022
Peer-reviewed
Oui
Volume
75
Number
6
Pages
426-430
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
The dynamics of metastatic evolution in clear cell renal cell carcinoma (ccRCC) are complex. We report a case study where tumour heterogeneity resulting from clonal evolution is a frequent feature and could play a role in metastatic dissemination.We used an integrative multiomics strategy combining genomic and transcriptomic data to classify fourteen specimens from spatially different areas of a kidney tumour and three non-primary sites including a vein thrombus and two adrenal metastases.All sites were heterogeneous and polyclonal, each tumour site containing two different aggressive subclonal populations, with differentially expressed genes implicated in distinct biological functions. These are rare primary metastatic samples prior to any medical treatment, where we showed a multiple metastatic seeding of two subclonal populations.Multiple interdependent lineages could be the source of metastatic heterogeneity in ccRCC. By sampling metastases, patients with resistance to therapies could benefit a combination of targeted therapies based on more than one aggressive clone.
Keywords
Adrenal Gland Neoplasms, Carcinoma, Renal Cell/genetics, Carcinoma, Renal Cell/pathology, Carcinoma, Renal Cell/therapy, Clone Cells/pathology, Genomics, Humans, Kidney Neoplasms/genetics, Kidney Neoplasms/pathology, Neoplasm Metastasis, kidney neoplasms, neoplasm metastasis, neoplasms
Pubmed
Web of science
Create date
28/06/2022 7:18
Last modification date
11/11/2023 7:10