Mortality associated with diabetes mellitus in comparison with history of cardiovascular disease in older women.

Details

Serval ID
serval:BIB_FEF0D7771A9A
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Mortality associated with diabetes mellitus in comparison with history of cardiovascular disease in older women.
Title of the conference
WONCA 2009, 15th European Conference of the World Organization of National Colleges, Academies and Academic Associations of General Practitioners/Family Physicians
Author(s)
Nanchen D., Rodondi N., Cornuz J., Hillier T., Ensrud K.E., Cauley J.A., Bauer Douglas C.
Address
Basel, Switzerland, September 16-19, 2009
ISBN
1424-7860
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
139
Series
Swiss Medical Weekly
Pages
19S
Language
english
Abstract
Current treatment guidelines consider diabetes to be equivalent to existing cardiovascular disease (CVD), but few data exist about the relative importance of these risk factors for total and CVD mortality in older women.We studied 9704 women aged >= 65 years enrolled in a prospective cohort study (Study of Osteoporotic Fracture) during a mean follow-up of 13 years and compared all-cause and CVD mortality among non-diabetic women without and with history of CVD at baseline and diabetic women without and with history of CVD. Diabetes mellitus and CVD were defined as self-report of physician diagnoses. Cause of death was adjudicated from death certificates and medical records when available. Ascertainment of vital status was 99% complete. Multivariate Cox hazard models adjusted for age, smoking, physical activity, systolic blood pressure, waist girth and education were used to compare mortality among the four groups with non-diabetic women without CVD as the referent group. At baseline mean age was 71.7 } 5.3 years, 7.0% reported diabetes mellitus and 14.5% reported prior CVD. 4257 women died during follow-up, 36.6% were attributed to CVD. Compared to non-diabetic women without prior CVD, the risk of CVD mortality was elevated among both non-diabetic women with CVD (HR = 1.82, 95% CI: 1.60-2.07, P <0.001) and diabetic women without prior CVD (HR = 2.24, CI: 1.87-2.69, P <0.001). CVD mortality was highest among diabetic women with CVD (HR = 3.41, CI: 2.61-4.45, P <0.001). Compared to non-diabetic women with CVD, diabetic women without prior CVD had a significantly higher adjusted HR for total and CVD mortality (P < 0.001 and P <0.05 respectively). Older diabetic women without prior CVD have a higher risk of all-cause and CVD mortality compared to nondiabetic women with pre-existing CVD. For older women, these data support the equivalence of prior CVD and diabetes mellitus in current guidelines for the prevention of CVD in primary care.
Keywords
Aged , Female , Mortality , Diabetes Mellitus/mortality , Cardiovascular Diseases
Create date
18/06/2010 10:43
Last modification date
20/08/2019 17:29
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