Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_FEC162E8CAAE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children.
Journal
European journal of pediatrics
Author(s)
Mouron-Hryciuk J., Cachat F., Parvex P., Perneger T., Chehade H.
ISSN
1432-1076 (Electronic)
ISSN-L
0340-6199
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Glomerular filtration rate (GFR) is difficult to measure, and estimating formulas are notorious for lacking precision. This study aims to assess if the inclusion of additional biomarkers improves the performance of eGFR formulas. A hundred and sixteen children with renal diseases were enrolled. Data for age, weight, height, inulin clearance (iGFR), serum creatinine, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) were collected. These variables were added to the revised and combined (serum creatinine and cystatin C) Schwartz formulas, and the quadratic and combined quadratic formulas. We calculated the adjusted r-square (r <sup>2</sup> ) in relation to iGFR and tested the improvement in variance explained by means of the likelihood ratio test. The combined Schwartz and the combined quadratic formulas yielded best results with an r <sup>2</sup> of 0.676 and 0.730, respectively. The addition of BNP and PTH to the combined Schwartz and quadratic formulas improved the variance slightly. NGAL and albumin failed to improve the prediction of GFR further. These study results also confirm that the addition of cystatin C improves the performance of estimating GFR formulas, in particular the Schwartz formula.Conclusion: The addition of serum NGAL, BNP, PTH, and albumin to the combined Schwartz and quadratic formulas for estimating GFR did not improve GFR prediction in our population. What is Known: • Estimating glomerular filtration rate (GFR) formulas include serum creatinine and/or cystatin C but lack precision when compared to measured GFR. • The serum concentrations of some biological parameters such as neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) vary with the level of renal function. What is New: • The addition of BNP and PTH to the combined quadratic formula improved its performance only slightly. NGAL and albumin failed to improve the prediction of GFR further.
Keywords
Albumin, Brain natriuretic peptide, Child, Glomerular filtration rate, Neutrophil gelatinase-associated lipocalin, Parathyroid hormone
Pubmed
Web of science
Open Access
Yes
Create date
29/03/2021 13:27
Last modification date
17/04/2021 7:13
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