Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury.

Details

Serval ID
serval:BIB_FEA1FDB5EF9C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury.
Journal
Journal of vascular surgery
Author(s)
Mauro C.R., Tao M., Yu P., Treviño-Villerreal J.H., Longchamp A., Kristal B.S., Ozaki C.K., Mitchell J.R.
ISSN
1097-6809 (Electronic)
ISSN-L
0741-5214
Publication state
Published
Issued date
02/2016
Peer-reviewed
Oui
Volume
63
Number
2
Pages
500-9.e1
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Whereas chronic overnutrition is a risk factor for surgical complications, long-term dietary restriction (reduced food intake without malnutrition) protects in preclinical models of surgical stress. Building on the emerging concept that acute preoperative dietary perturbations can affect the body's response to surgical stress, we hypothesized that short-term high-fat diet (HFD) feeding before surgery is detrimental, whereas short-term nutrient/energy restriction before surgery can reverse negative outcomes. We tested this hypothesis in two distinct murine models of vascular surgical injury, ischemia-reperfusion (IR) and intimal hyperplasia (IH).
Short-term overnutrition was achieved by feeding mice a HFD consisting of 60% calories from fat for 2 weeks. Short-term dietary restriction consisted of either 1 week of restricted access to a protein-free diet (protein/energy restriction) or 3 days of water-only fasting immediately before surgery; after surgery, all mice were given ad libitum access to a complete diet. To assess the impact of preoperative nutrition on surgical outcome, mice were challenged in one of two fundamentally distinct surgical injury models: IR injury to either kidney or liver, or a carotid focal stenosis model of IH.
Three days of fasting or 1 week of preoperative protein/energy restriction attenuated IH development measured 28 days after focal carotid stenosis. One week of preoperative protein/energy restriction also reduced plasma urea, creatinine, and damage to the corticomedullary junction after renal IR and decreased aspartate transaminase, alanine transaminase, and hemorrhagic necrosis after hepatic IR. However, exposure to a HFD for 2 weeks before surgery had no significant impact on kidney or hepatic function after IR or IH after focal carotid stenosis.
Short-term dietary restriction immediately before surgery significantly attenuated the vascular wall hyperplastic response and improved IR outcome. The findings suggest plasticity in the body's response to these vascular surgical injuries that can be manipulated by novel yet practical preoperative dietary interventions.
Keywords
Animals, Biomarkers/blood, Caloric Restriction, Carotid Stenosis/diet therapy, Carotid Stenosis/etiology, Carotid Stenosis/pathology, Creatinine/blood, Diet, High-Fat, Diet, Protein-Restricted, Disease Models, Animal, Energy Intake, Kidney/blood supply, Kidney/pathology, Liver/blood supply, Liver/pathology, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Neointima, Preoperative Care, Reperfusion Injury/blood, Reperfusion Injury/etiology, Reperfusion Injury/pathology, Reperfusion Injury/prevention & control, Time Factors, Urea/blood
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / P1LAP3_158895
Create date
07/03/2021 13:59
Last modification date
08/03/2021 7:26
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