Are standard human coagulation tests suitable in pigs and calves during extracorporeal circulation?

Details

Serval ID
serval:BIB_FE8D4CDAC862
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Are standard human coagulation tests suitable in pigs and calves during extracorporeal circulation?
Journal
Artificial Organs
Author(s)
Mueller  X. M., Tevaearai  H. T., Jegger  D., Tucker  O., von Segesser  L. K.
ISSN
0160-564X (Print)
Publication state
Published
Issued date
07/2001
Volume
25
Number
7
Pages
579-84
Notes
Comparative Study
Journal Article --- Old month value: Jul
Abstract
The thrombogenicity of membrane oxygenators as well as clotting parameters profiles, using standard human clotting tests, was analyzed in calves and pigs during 6 h perfusion. Three calves and 3 pigs were connected to extracorporeal circulation with standard heparinization. Blood samples were taken for coagulation variables throughout perfusion, and oxygenators were examined for clot deposits at the end of the experiment. Two out of 3 oxygenators of the calf group presented clot deposits while none in the pig group did. Baseline coagulation variables of pigs showed values similar to those of humans while neither extrinsic nor intrinsic pathways could be activated in calves with standard human coagulation tests. The calf model, in conclusion, was confirmed to be a difficult model for the testing of extracorporeal circulation device resistance to thrombus formation, which is, however, not reflected by standard human coagulation tests. The pig model is a better model in which both coagulation pathways could be activated with standard human coagulation tests.
Keywords
Adult Analysis of Variance Animals *Blood Coagulation Tests Cardiopulmonary Bypass/methods Cattle Disease Models, Animal Extracorporeal Circulation/*methods Hemodynamic Processes/physiology Heparin/pharmacology Humans Monitoring, Physiologic/methods Probability Sensitivity and Specificity Species Specificity Swine Thromboembolism/prevention & control
Pubmed
Web of science
Create date
28/01/2008 10:28
Last modification date
20/08/2019 17:29
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