Dissociation between allogeneic T cell stimulation and interleukin-1 or tumor necrosis factor production by human lung dendritic cells.

Details

Serval ID
serval:BIB_FE6093A2F2DA
Type
Article: article from journal or magazin.
Collection
Publications
Title
Dissociation between allogeneic T cell stimulation and interleukin-1 or tumor necrosis factor production by human lung dendritic cells.
Journal
American Journal of Respiratory Cell and Molecular Biology
Author(s)
Nicod L.P., Galve-de Rochemonteix B., Dayer J.M.
ISSN
1044-1549[print], 1044-1549[linking]
Publication state
Published
Issued date
1990
Volume
2
Number
6
Pages
515-522
Language
english
Abstract
A small portion of human lung mononuclear cells are very potent stimulators of allogeneic resting T cells. Although several-fold more effective than phagocytic alveolar macrophages (AM) and blood monocytes (Mo), they do not produce more of the lymphocyte co-stimulators interleukin-1-alpha (IL-1 alpha), interleukin-1-beta (IL-1 beta), or tumor necrosis factor-alpha (TNF-alpha) than did Mo. Blocking antibodies against IL-1 alpha, IL-1 beta, TNF-alpha, and IL-6 did not reduce T cell proliferation. These potent antigen-presenting cells (APC) are loosely adherent and do not have phagocytic inclusions. Most of them have the marker RFD1 of dendritic cells (DC) rarely present on Mo or AM and have a strong tendency to form clusters with T cells like murine DC. Thus, we demonstrate an example in the human system of a dissociation between T cell activation and IL-1 or TNF-alpha production by DC or Mo, implying a major role for other "co-stimulating signals" by lung APC with dendritic features. The presence of different APC with various co-stimulating signals may be of importance for T cell subsets modulation.
Keywords
Antibodies/immunology, Antigen-Presenting Cells/drug effects, Antigen-Presenting Cells/immunology, Binding, Competitive, Humans, Interleukin-1/biosynthesis, Lipopolysaccharides/pharmacology, Lung/drug effects, Lung/immunology, Lymphocyte Activation/drug effects, Lymphocyte Activation/immunology, T-Lymphocytes/drug effects, T-Lymphocytes/immunology, Tumor Necrosis Factor-alpha/biosynthesis
Pubmed
Web of science
Create date
19/02/2010 19:00
Last modification date
20/08/2019 17:29
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