Mixed exocrine-neuroendocrine carcinoma of the nasal cavity: clinico-pathologic and molecular study of a case and review of the literature.

Details

Serval ID
serval:BIB_FE5313673881
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Mixed exocrine-neuroendocrine carcinoma of the nasal cavity: clinico-pathologic and molecular study of a case and review of the literature.
Journal
Head and Neck Pathology
Author(s)
La Rosa S., Furlan D., Franzi F., Battaglia P., Frattini M., Zanellato E., Marando A., Sahnane N., Turri-Zanoni M., Castelnuovo P., Capella C.
ISSN
1936-0568 (Electronic)
ISSN-L
1936-055X
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
7
Number
1
Pages
76-84
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
Sinonasal intestinal-type adenocarcinomas (ITACs) are rare neoplasms histologically resembling intestinal adenocarcinomas. Although a neuroendocrine differentiation in ITACs has been described, true mixed exocrine-neuroendocrine carcinomas, neoplasms in which each component represents at least 30 % of the lesion, are extremely rare and their molecular alterations are largely unknown. We describe herein the clinico-pathologic features, the methylation profile, chromosomal gains and losses, and mutation analysis of KRAS, BRAF and p53 in a nasal mixed exocrine-neuroendocrine carcinoma resected in a 79-year-old man. The tumor was composed of an ITAC and a poorly differentiated neuroendocrine carcinoma. Both exocrine and neuroendocrine components were CK8, CK20, CDX2 and p53 positive, and CK7 and TTF1 negative. The neuroendocrine component also showed immunoreactivity for chromogranin A, synaptophysin, serotonin and glicentin. Gains and losses were found at following chromosome regions: 17p13 (TP53), 14q24 (MLH3), 19q13 (KLK3), 5q21 (APC), 7q21 (CDK6), 9q34 (DAPK1), 12p13 (TNFRSF 1A, CDKN1B), 13q12 (BRCA2), 17p13.3 (HIC1), 18q21 (BCL2), and 22q12 (TIMP3). Aberrant methylation was detected only in the neuroendocrine component and involved APC and DAPK1 genes. No mutation of KRAS (exons 2-4), BRAF (exon 15), and p53 (exons 4-10) was found in both components. The results suggest a monoclonal origin of the tumor from a pluripotent cell undergoing a biphenotypic differentiation and that the neuroendocrine differentiation may be from an exocrine to an endocrine pathway. We have also reviewed the literature on sinonasal mixed exocrine-neuroendocrine carcinomas to give to the reader a comprehensive overview of these very rare tumor types.
Keywords
Adenocarcinoma/genetics, Adenocarcinoma/metabolism, Aged, Biomarkers, Tumor/analysis, Carcinoma, Neuroendocrine/genetics, Carcinoma, Neuroendocrine/metabolism, DNA Mutational Analysis, Humans, Immunohistochemistry, Male, Nasal Cavity/pathology, Neoplasms, Complex and Mixed/genetics, Neoplasms, Complex and Mixed/metabolism, Nose Neoplasms/genetics, Nose Neoplasms/metabolism
Pubmed
Create date
06/09/2016 13:00
Last modification date
20/08/2019 16:28
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