Thyroid-Associated Orbitopathy and Biomarkers: Where We Are and What We Can Hope for the Future.

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Version: Author's accepted manuscript
Secondary document(s)
Download: DM2018-7010196.pdf (1404.34 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_FE0BCCA11C68
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Thyroid-Associated Orbitopathy and Biomarkers: Where We Are and What We Can Hope for the Future.
Journal
Disease markers
Author(s)
Turck N., Eperon S., De Los Angeles Gracia M., Obéric A., Hamédani M.
ISSN
1875-8630 (Electronic)
ISSN-L
0278-0240
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
2018
Pages
7010196
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Thyroid-associated orbitopathy (TAO) is the most common autoimmune disease of the orbit. It occurs more often in patients presenting with hyperthyroidism, characteristic of Graves' disease, but may be associated with hypothyroidism or euthyroidism. The diagnosis of TAO is based on clinical orbital features, radiological criteria, and the potential association with thyroid disease. To date, there is no specific marker of the orbital disease, making the early diagnosis difficult, especially if the orbital involvement precedes the thyroid dysfunction.
The goal of this review is to present the disease and combine the available data in the literature concerning investigation of TAO biomarkers.
Despite the progress done in the understanding of TAO disease, some important pieces are still missing. Typically, for the future, major efforts have to be done in the discovery of new biomarkers, validation of the suspected candidates on multicenter cohorts with standardized methodologies, and establishment of their clinical performances on the specific clinical application fields in order to improve not only the management of the TAO patients but also the therapeutic options and follow-up.
Pubmed
Web of science
Open Access
Yes
Create date
12/05/2018 9:59
Last modification date
20/08/2019 17:28
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