The fitness landscape of the codon space across environments.

Details

Serval ID
serval:BIB_FE09A1EFBA24
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The fitness landscape of the codon space across environments.
Journal
Heredity
Author(s)
Fragata I., Matuszewski S., Schmitz M.A., Bataillon T., Jensen J.D., Bank C.
ISSN
1365-2540 (Electronic)
ISSN-L
0018-067X
Publication state
Published
Issued date
11/2018
Peer-reviewed
Oui
Volume
121
Number
5
Pages
422-437
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Fitness landscapes map the relationship between genotypes and fitness. However, most fitness landscape studies ignore the genetic architecture imposed by the codon table and thereby neglect the potential role of synonymous mutations. To quantify the fitness effects of synonymous mutations and their potential impact on adaptation on a fitness landscape, we use a new software based on Bayesian Monte Carlo Markov Chain methods and re-estimate selection coefficients of all possible codon mutations across 9 amino acid positions in Saccharomyces cerevisiae Hsp90 across 6 environments. We quantify the distribution of fitness effects of synonymous mutations and show that it is dominated by many mutations of small or no effect and few mutations of larger effect. We then compare the shape of the codon fitness landscape across amino acid positions and environments, and quantify how the consideration of synonymous fitness effects changes the evolutionary dynamics on these fitness landscapes. Together these results highlight a possible role of synonymous mutations in adaptation and indicate the potential mis-inference when they are neglected in fitness landscape studies.
Pubmed
Web of science
Create date
29/08/2018 15:06
Last modification date
21/08/2019 6:15
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