Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficiencies.

Details

Serval ID
serval:BIB_FDE48CDB2139
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficiencies.
Journal
Analytical biochemistry
Author(s)
Rackayova V., Cudalbu C., Pouwels PJW, Braissant O.
ISSN
1096-0309 (Electronic)
ISSN-L
0003-2697
Publication state
Published
Issued date
15/07/2017
Peer-reviewed
Oui
Volume
529
Pages
144-157
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Creatine (Cr) is an important organic compound acting as intracellular high-energy phosphate shuttle and in energy storage. While located in most cells where it plays its main roles in energy metabolism and cytoprotection, Cr is highly concentrated in muscle and brain tissues, in which Cr also appears to act in osmoregulation and neurotransmission. This review discusses the basis of Cr metabolism, synthesis and transport within brain cells. The importance of Cr in brain function and the consequences of its impaired metabolism in primary and secondary Cr deficiencies are also discussed. Cr and phosphocreatine (PCr) in living systems can be well characterized using in vivo magnetic resonance spectroscopy (MRS). This review describes how (1)H MRS allows the measurement of Cr and PCr, and how (31)P MRS makes it possible to estimate the creatine kinase (CK) rate constant and so detect dynamic changes in the Cr/PCr/CK system. Absolute quantification by MRS using creatine as internal reference is also debated. The use of in vivo MRS to study brain Cr in a non-invasive way is presented, as well as its use in clinical and preclinical studies, including diagnosis and treatment follow-up in patients.

Keywords
Animals, Brain/metabolism, Brain Diseases/metabolism, Brain Diseases/pathology, Creatine/deficiency, Creatine/metabolism, Energy Metabolism, Humans, Magnetic Resonance Imaging/methods, Magnetic Resonance Spectroscopy/methods, Models, Biological, (1)H MRS, (31)P MRS, Brain, Creatine, Creatine deficiencies, Guanidinoacetate
Pubmed
Web of science
Create date
05/12/2016 19:26
Last modification date
20/08/2019 17:28
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