Increased axonal regrowth of lesioned rat sciatic nerve by veratrylguanidine methane sulfonate.

Details

Serval ID
serval:BIB_FDD966595040
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased axonal regrowth of lesioned rat sciatic nerve by veratrylguanidine methane sulfonate.
Journal
Neurochemistry International
Author(s)
Becherer U., Kuchler-Bopp S., Aubert F., Rousseau B., Riederer B.M., Renko D., Quirosa-Guillou C., Thal C., Zanetta J.P.
ISSN
0197-0186 (Print)
ISSN-L
0197-0186
Publication state
Published
Issued date
1995
Volume
26
Number
3
Pages
245-254
Language
english
Abstract
Neurotrophic factors appear as essential factors for normal development and repair of the nervous tissue. Veratrylguanidine methane sulfonate, has been shown to induce important neurite outgrowth of cultured dorsal root ganglia isolated from newborn rats. Its action was similar to that of NGF and was found to be additive to that of NGF. In order to see if this compound was able to stimulate axonal growth in adult animals, we examined the effect of this substance on the regeneration of the lesioned sciatic nerve. Using histochemical, immunohistochemical and ultrastructural studies, it is shown that a single intraperitoneal injection of veratrylguanidine methane sulfonate significantly increases the axonal growth during repair of the adult rat sciatic nerve. The efficiency of this substance is explained by its good targeting and long life time in the sciatic nerve.
Keywords
Animals, Axons/drug effects, Axons/physiology, Cells, Cultured, Denervation, Guanidines/pharmacology, Histocytochemistry, Immunohistochemistry, Male, Microscopy, Electron, Nerve Regeneration, Rats, Rats, Wistar, Schwann Cells/physiology, Sciatic Nerve/cytology, Sciatic Nerve/drug effects
Pubmed
Web of science
Create date
24/01/2008 15:34
Last modification date
20/08/2019 17:28
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