Infection à Mycobacterium tuberculosis: Signification, rôle et performance des tests immunologiques [Mycobacterium tuberculosis infection: signification, role and performance of mesure of cell-mediated immune response]

Details

Serval ID
serval:BIB_FDB9D94EBBD2
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Infection à Mycobacterium tuberculosis: Signification, rôle et performance des tests immunologiques [Mycobacterium tuberculosis infection: signification, role and performance of mesure of cell-mediated immune response]
Journal
Revue medicale suisse
Author(s)
Glardon D., Erard V.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
09/04/2014
Peer-reviewed
Oui
Volume
10
Number
425
Pages
816-819
Language
french
Notes
Publication types: Case Reports ; Comparative Study ; English Abstract ; Journal Article
Publication Status: ppublish
Abstract
Mycobacterium tuberculosis infection: signification, role and performance of mesure of cell-mediated immune response The tuberculin skin test (TST) and IGRAs are to date the unique way to identify individuals latently infected with Mycobacterium tuberculosis. In contrast to IGRAs, test specificity of TST is clearly affected by prior vaccination with attenuated strain M. bovis (BCG). Moreover, there is evidence suggesting that the accuracy of IGRAs is higher than that of TST and therefore IGRAs should perform better to detect latent tuberculosis in immunosuppressed individuals. However, neither TST nor IGRAs permit to discriminate between latent and active infection. Furthermore, there is no available test capable to identify whether individual with latent infection harbor live or dead mycobacteria and thus to detect who is at risk to develop active tuberculosis.
Keywords
Aged, BCG Vaccine/administration & dosage, Female, Humans, Interferon-gamma Release Tests/methods, Latent Tuberculosis/diagnosis, Latent Tuberculosis/immunology, Male, Middle Aged, Mycobacterium tuberculosis/isolation & purification, Sensitivity and Specificity, Tuberculin Test/methods
Pubmed
Create date
02/03/2022 21:08
Last modification date
03/05/2023 9:34
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