Platelet-activating factor does not induce bronchial hyperreactivity in nonasthmatic subjects

Details

Serval ID
serval:BIB_FDB92EEF0FD1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Platelet-activating factor does not induce bronchial hyperreactivity in nonasthmatic subjects
Journal
Respiration
Author(s)
Gebremichael  I., Leuenberger  P.
ISSN
0025-7931 (Print)
Publication state
Published
Issued date
1992
Volume
59
Number
4
Pages
193-6
Notes
Journal Article
Abstract
Platelet-activating factor (PAF) is a phospholipid which plays a role as a mediator in inflammation. Recently, it has been implicated in the induction of bronchial hyperresponsiveness in man. In order to establish the effect of PAF on bronchial reactivity, 6 normal subjects without bronchial hyperresponsiveness inhaled 400 micrograms of PAF in 10 divided cumulative doses. All subjects felt a hot flush and a slight tracheal irritation after the inhalation of PAF. Forced expiratory flows (FEF) were measured between each inhalation of PAF and did not change significantly. Bronchial reactivity to methacholine (MCH up to a dose of 2 mg) was determined 1, 7, 14 and 21 days after inhalation of PAF. Forced expiratory volume in 1 s (FEV1), forced expiratory flow between 25 and 75%, and at 75% of vital capacity (FEF25-75% and FEF75%) measured after the inhalation of 2 mg of MCH did not differ significantly from baseline values determined before PAF challenge. In conclusion, the administration of PAF by inhalation in tolerable doses does not induce bronchial hyperresponsiveness as determined by a reduction of 20% of FEV1 nor by more sensitive indicators of ventilatory obstruction, such as FEF25-75% and FEF75%.
Keywords
Administration, Inhalation Adult Asthma/physiopathology Bronchial Hyperreactivity/etiology/*physiopathology Bronchial Provocation Tests Female Follow-Up Studies Forced Expiratory Flow Rates Humans Male Platelet Activating Factor/adverse effects/*pharmacology Spirometry
Pubmed
Web of science
Create date
25/01/2008 10:50
Last modification date
20/08/2019 17:28
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