Statin treatment is associated with improved prognosis in patients with AF-related stroke.

Details

Serval ID
serval:BIB_FDB9180884D9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Statin treatment is associated with improved prognosis in patients with AF-related stroke.
Journal
International Journal of Cardiology
Author(s)
Ntaios G., Papavasileiou V., Makaritsis K., Milionis H., Manios E., Michel P., Lip G.Y., Vemmos K.
ISSN
1874-1754 (Electronic)
ISSN-L
0167-5273
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
177
Number
1
Pages
129-133
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
BACKGROUND/OBJECTIVES: The most recent ACC/AHA guidelines recommend high-intensity statin therapy in ischemic stroke patients of presumably atherosclerotic origin. On the contrary, there is no specific recommendation for the use of statin in patients with non-atherosclerotic stroke, e.g. strokes related to atrial fibrillation (AF). We investigated whether statin treatment in patients with AF-related stroke is associated with improved survival and reduced risk for stroke recurrence and future cardiovascular events.
METHODS: All consecutive patients registered in the Athens Stroke Registry with AF-related stroke and no history of coronary artery disease nor clinically manifest peripheral artery disease were included in the analysis and categorized in two groups depending on whether statin was prescribed at discharge. The primary outcome was overall mortality; the secondary outcomes were stroke recurrence and a composite cardiovascular endpoint comprising of recurrent stroke, myocardial infarction, aortic aneurysm rupture or sudden cardiac death during the 5-year follow-up.
RESULTS: Among 1602 stroke patients, 404 (25.2%) with AF-related stroke were included in the analysis, of whom 102 (25.2%) were discharged on statin. On multivariate Cox-proportional-hazards model, statin treatment was independently associated with a lower mortality (hazard-ratio (HR): 0.49, 95%CI:0.26-0.92) and lower risk for the composite cardiovascular endpoint during the median 22months follow-up (HR: 0.44, 95%CI:0.22-0.88), but not with stroke recurrence (HR: 0.47, 95%CI:0.22-1.01, p: 0.053).
CONCLUSIONS: In this long-term registry of patients with AF-related stroke, statin treatment was associated with improved survival and reduced risk for future cardiovascular events.
Pubmed
Web of science
Create date
27/12/2014 11:47
Last modification date
20/08/2019 17:28
Usage data