Recent advances in the management of atypical meningiomas.

Details

Serval ID
serval:BIB_FD65BBDB7034
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Recent advances in the management of atypical meningiomas.
Journal
Neuro-Chirurgie
Author(s)
Messerer M., Richoz B., Cossu G., Dhermain F., Hottinger A.F., Parker F., Levivier M., Daniel R.T.
ISSN
1773-0619 (Electronic)
ISSN-L
0028-3770
Publication state
Published
Issued date
04/2016
Peer-reviewed
Oui
Volume
62
Number
4
Pages
213-222
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Based on the 2007 WHO classification, the proportion of atypical meningiomas has steeply increased. Complete resection is usually considered curative, however, the recurrence rate remains high. The treatment of more aggressive meningiomas remains problematic. We performed a literature review via the PubMed database with specific attention to radiological, pathological, genetic and molecular aspects particular to WHO grade II meningiomas and current therapeutic strategies. We also reviewed the role of surgery and summarized the results of the principal studies dealing with adjuvant strategies based on the most recent evidence. Adjuvant radiotherapy, administered as stereotactic radiosurgery or conventional external beam irradiation, should be strongly considered in selected cases. Limited data exist regarding the role of hormonal treatment or chemotherapy as adjunct therapy. A target therapy modulating the altered molecular balance may be the key to revolutionize the prognosis of these patients.

Keywords
Combined Modality Therapy/methods, Humans, Meningeal Neoplasms/diagnosis, Meningeal Neoplasms/surgery, Meningioma/diagnosis, Meningioma/surgery, Neoplasm Recurrence, Local/diagnosis, Neoplasm Recurrence, Local/surgery, Radiosurgery/methods, Radiotherapy, Adjuvant/methods, Retrospective Studies, Treatment Outcome
Pubmed
Create date
12/09/2016 13:16
Last modification date
20/08/2019 17:28
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