Four-hour infusions of synthetic atrial natriuretic peptide in normal volunteers.

Details

Serval ID
serval:BIB_FD5FE7F08CA4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Four-hour infusions of synthetic atrial natriuretic peptide in normal volunteers.
Journal
Hypertension
Author(s)
Biollaz J., Nussberger J., Porchet M., Brunner-Ferber F., Otterbein E.S., Gomez H., Waeber B., Brunner H.R.
ISSN
0194-911X
Publication state
Published
Issued date
1986
Peer-reviewed
Oui
Volume
8
Number
6 Pt 2
Pages
II96-105
Language
english
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Two doses of synthetic atrial natriuretic peptide (0.5 and 5.0 micrograms/min) and its vehicle were infused intravenously for 4 hours in eight salt-loaded normal volunteers, and the effect on blood pressure, heart rate, renal hemodynamics, solute excretion, and secretion of vasoactive hormones was studied. The 0.5 micrograms/min infusion did not alter blood pressure or heart rate, whereas the 5.0 micrograms/min infusion significantly reduced the mean pressure by 20/9 mm Hg after 2.5 to 3 hours and increased the heart rate slightly. Inulin clearance was not significantly changed, but the mean p-aminohippurate clearance fell by 13 and 32% with the lower and higher doses, respectively. Urinary excretion of sodium and chloride increased slightly with the lower dose. With the higher dose, a marked increase in urinary excretion of sodium, chloride, and calcium was observed, reaching a peak during the second hour of the infusion. Potassium and phosphate excretion did not change significantly. A brisk increase in urine flow rate and fractional water excretion was seen only during the first hour of the high-dose infusion. Signs and symptoms of hypotension were observed in two subjects. No change in plasma renin activity, angiotensin II, or aldosterone was observed during either infusion, but a marked increase occurred after discontinuation of the high-dose infusion. In conclusion, the 5 micrograms/min infusion induced a transient diuretic effect, delayed maximal natriuretic activity, and a late fall in blood pressure, with no change in inulin clearance but a dose-related decrease in p-aminohippurate clearance. Despite large amounts of sodium excreted and blood pressure reduction, no counterregulatory changes were observed in the renin-angiotensin-aldosterone system or plasma vasopressin levels during the infusion.
Keywords
Adult, Aldosterone, Angiotensin II, Atrial Natriuretic Factor, Blood Pressure, Body Water, Calcium, Chlorides, Glomerular Filtration Rate, Heart Rate, Humans, Kidney, Male, Metabolic Clearance Rate, Natriuresis, Phosphates, Potassium, Renin, Sodium, p-Aminohippuric Acid
Pubmed
Create date
05/03/2008 17:39
Last modification date
20/08/2019 17:28
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