HLA-G expression in basal cell carcinomas of the skin recurring after radiotherapy

Details

Serval ID
serval:BIB_FD4D860DC31F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
HLA-G expression in basal cell carcinomas of the skin recurring after radiotherapy
Journal
Clinical and Experimental Dermatology
Author(s)
Urosevic  M., Kempf  W., Zagrodnik  B., Panizzon  R., Burg  G., Dummer  R.
ISSN
0307-6938 (Print)
Publication state
Published
Issued date
07/2005
Volume
30
Number
4
Pages
422-5
Notes
Journal Article --- Old month value: Jul
Abstract
Basal cell carcinoma (BCC) of the skin represents the most common malignancy in the fair-skinned population worldwide. HLA-G is one of the molecules implicated in immunotolerance. To investigate the role of HLA-G in recurring BCCs, we constructed a tissue microarray containing 38 primary BCCs that underwent radiotherapy and 14 secondary BCCs recurring on the primary site after radiotherapy, and evaluated the HLA-G protein expression by immunohistochemistry. The HLA-G protein was most frequently expressed in aggressive sclerosing BCCs. Nodular BCC demonstrated the strongest HLA-G expression. Interestingly, tumor infiltrating mononuclear cells (TIMC) expressed the HLA-G molecule in BCCs that showed no recurrence. After comparing primary BCCs and BCCs relapsed after radiotherapy, we observed decreased HLA-G expression on tumor cells and the loss of HLA-G expression on TIMC in relapsed BCCs. After radiotherapy, immunobiology of BCC may change resulting in the down-regulation of HLA-G expression on tumor and on tumor-infiltrating cells.
Keywords
Carcinoma, Basal Cell/*immunology/radiotherapy Follow-Up Studies HLA Antigens/*metabolism Histocompatibility Antigens Class I/*metabolism Humans Immune Tolerance Immunoenzyme Techniques Neoplasm Recurrence, Local/*immunology Retrospective Studies Skin Neoplasms/*immunology/radiotherapy
Pubmed
Web of science
Create date
25/01/2008 16:55
Last modification date
20/08/2019 16:28
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