Ventilation-induced lung injury is associated with an increase in gut permeability

Details

Serval ID
serval:BIB_FD2BB909BE82
Type
Article: article from journal or magazin.
Collection
Publications
Title
Ventilation-induced lung injury is associated with an increase in gut permeability
Journal
Shock
Author(s)
Guery B. P., Welsh D. A., Viget N. B., Robriquet L., Fialdes P., Mason C. M., Beaucaire G., Bagby G. J., Neviere R.
ISSN
1073-2322 (Print)
ISSN-L
1073-2322
Publication state
Published
Issued date
06/2003
Volume
19
Number
6
Pages
559-63
Language
english
Notes
Guery, Benoit P
Welsh, David A
Viget, Nathalie B
Robriquet, Laurent
Fialdes, Patrice
Mason, Carol M
Beaucaire, Gilles
Bagby, Greg J
Neviere, Remi
eng
Shock. 2003 Jun;19(6):559-63. doi: 10.1097/01.shk.0000070738.34700.bf.
Abstract
Mechanical ventilation is associated with several harmful effects mainly related to high tidal volumes (Vt). Ventilator-induced lung injury can be responsible for an increased production of inflammatory mediators. We evaluated remote consequences on the gut of lung triggered inflammatory response, neutralizing anti-tumor necrosis factor (TNF) antibody was administered to assess the role of TNF in lung and gut permeability changes. Rats were anesthetized and ventilated for 2 h. A control group (Con: Vt = 10 mL/kg) was compared with a high Vt group (HV: Vt = 30 ml/kg). One microCi of I125-labeled human serum albumin was injected to measure extravascular albumin space. Gut permeability was evaluated by plasma-to-lumen ratio leakage of I125 human serum albumin. Extravascular albumin space increased in the HV group from 446 +/- 50 microL to 2783 +/- 887 microL. Gut index of permeability increased from 5.1 +/- 1.2 to 14.2 +/- 4.9. Anti-TNF antibody prevented both lung and gut increase in permeability. High tidal volume ventilation resulted in an increase in lung edema and gut permeability, antagonism of TNF with neutralizing antibodies abrogated the increase in gut permeability as well as lung edema.
Keywords
Animals, Antibodies/*pharmacology, Cell Membrane Permeability/drug effects/*physiology, Disease Models, Animal, Gastrointestinal Motility/drug effects/*physiology, Oxygen/blood, Partial Pressure, Rats, Rats, Sprague-Dawley, Respiration, Artificial/*adverse effects, Respiratory Distress Syndrome/*etiology/physiopathology, Tidal Volume, Tumor Necrosis Factor-alpha/*immunology
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
Usage data