Acoustic radiation force impulse sonography in assessing children with biliary atresia for liver transplantation.

Details

Serval ID
serval:BIB_FD01FDD506C3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Acoustic radiation force impulse sonography in assessing children with biliary atresia for liver transplantation.
Journal
Pediatric radiology
Author(s)
Hanquinet S., Courvoisier D.S., Rougemont A.L., Wildhaber B.E., Merlini L., McLin V.A., Anooshiravani M.
ISSN
1432-1998 (Electronic)
ISSN-L
0301-0449
Publication state
Published
Issued date
06/2016
Peer-reviewed
Oui
Volume
46
Number
7
Pages
1011-1016
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Children with biliary atresia are prone to developing progressive hepatic fibrosis and biliary cirrhosis following the Kasai operation. The only treatment is liver transplantation.
To assess liver fibrosis by acoustic radiation force impulse elastography (ARFI) in children who had Kasai operation, with the goal of identifying an ARFI value cut-off for children requiring liver transplantation.
Of the 32 post-Kasai children included, 19 were transplanted or listed for transplantation (group A), while 13 were not on the list during their follow-up (group B). We recorded biopsies, blood samples and ARFI values over time, including at Kasai operation and at transplantation. We estimated an association between groups and continuous variables using generalized estimating equations, and we compared categorical variables using the Fisher exact test.
Portal hypertension signs were similar in both groups, whereas ARFI values were higher in group A (mean±standard deviation=3.3±1.2 m/s) than in group B (2.0±0.7 m/s; P=.0003). Eighteen of 19 (94.7%) children in group A and 6/13 (46.2%) children in group B presented with two consecutive ARFI values ≥2 m/s (sensitivity=7%, specificity=53.8%; P=0.003).
We found that children who were transplanted had two consecutive ARFI values ≥2 m/s during follow-up. ARFI for evaluation of post-Kasai liver fibrosis may assist the long-term assessment of biliary atresia and may even guide treatment decisions.

Keywords
Acoustic radiation force impulse elastography (ARFI), Biliary atresia, Children, Cholestasis, Kasai operation, Liver stiffness, Liver transplantation, Shearwave elastography, Ultrasound
Pubmed
Create date
25/11/2016 13:49
Last modification date
20/08/2019 17:28
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