Epidermal growth factor receptors in human tumors of the central nervous system.

Details

Serval ID
serval:BIB_FCDCD4A61DDD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Epidermal growth factor receptors in human tumors of the central nervous system.
Journal
Anticancer Research
Author(s)
Baugnet-Mahieu L., Lemaire M., Brotchi J., Levivier M., Born J., Gilles J., Valkenaers-Michaux A., Vangheel V.
ISSN
0250-7005 (Print)
ISSN-L
0250-7005
Publication state
Published
Issued date
1990
Peer-reviewed
Oui
Volume
10
Number
5A
Pages
1275-1280
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Epidermal growth factor receptors (EGF-R) have been measured in human tumors of the Central Nervous System (CNS) by 125I EGF ligand binding. High affinity receptors (Ka congruent to 1 x 10(9) M-1) were detected in nearly all individual specimens of meningiomas and tumors of glial origin (astrocytomas, glioblastomas). The phosphotyrosine kinase activity associated with the EGF-R was evaluated by measuring the incorporation of gamma 32P-ATP, after immunoprecipitation of the receptor with the monoclonal antibody EGFRI. A good relationship was observed between the EGF-binding capacity and the autophosphorylation of the receptor, indicating that in most cases functional molecules of EGF-R were expressed on the tumor membranes. In the group of meningiomas, no relationship could be established between the EGF-R level and the histopathology of the tumors. Astrocytomas exemplify a progression of malignancy, from benign (low grade astrocytomas) towards an increased malignant phenotype (glioblastomas). In this group, our observations indicate a positive relationship between the EGF-R level and phosphokinase activity and the degree of malignancy.
Keywords
Brain Neoplasms/chemistry, Epidermal Growth Factor/metabolism, Humans, Phosphorylation, Receptor, Epidermal Growth Factor/analysis, Receptor, Epidermal Growth Factor/metabolism, Tyrosine/metabolism
Pubmed
Web of science
Create date
20/01/2008 17:36
Last modification date
20/08/2019 16:27
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