Predictors of favourable outcome in first-episode patients who refuse medication: results from the FEPOS study

Details

Serval ID
serval:BIB_FCB8B5FE9367
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Predictors of favourable outcome in first-episode patients who refuse medication: results from the FEPOS study
Title of the conference
From neurobiology to public policy. Abstracts of the 8th International Conference on Early Psychosis: From Neurobiology to Public Policy
Author(s)
Conus Philippe, Cotton Sue, Schimmelmann Benno, McGorry Patrick, Lambert Martin
Address
Oct 11-13, 2012; San Francisco, CA, United States
ISBN
1751-7893
ISSN-L
1751-7885
Publication state
Published
Issued date
2012
Volume
6
Series
Early Intervention in Psychiatry
Pages
35
Language
english
Abstract
There are suggestions that some first-episode psychosis (FEP) patients can have favourable outcome without antipsychotic medication. However, there is very limited data regarding patients' characteristics on which the decision to propose medication free treatment could be based. FEPOS is a fi le-based study of an epidemiological sample of 704 FEP patients treated at EPPIC, Melbourne, between 1998 and 2000. Among the 661 patients where data was available, 108 consistently refused medication during the entire duration of their treatment at EPPIC. In this paper we compared, within this sub-group, patients who had a favourable outcome with those who did not. Patients were aged between 15 and 29 years (M = 21.9, SD = 3.40) and the majority were male (70.4%, n = 76). Symptomatic remission data was available on 105 patients; of these patients 41.0% (n = 41) had achieved remission. Functional remission data was available on 100 patients; of these patients 33.0% (n = 33) had achieved functional remission. Combined remission was evident in 23.0% (n = 23) of patients. Three factors were associated with symptomatic remission: better premorbid functioning (based on GAF, OR = 1.07, p = 0.006), higher number of years of education (OR = 1.43, p = 0.020), and being employed or studying at service entry (OR = 2.59, p = 0.034). Three factors were associated with functional remission: shorter duration of prodrome (OR = 0.50, p = 0.043), severity of psychopathology (CGI-S, OR = 0.51, p = 0.024), and vocational status at service entry (OR = 4.29, p = 0.003). While various aspects of pre-morbid functioning seem to correlate with the possibility of a favourable outcome in FEP patients who refuse medication, various limitations need to be taken into account in this study.
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Create date
12/12/2012 16:34
Last modification date
20/08/2019 16:27
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