Fate of potentially self-reactive T cells in neonatal mice: analysis of V beta 6+ T cells in Mlsa mice

Details

Serval ID
serval:BIB_FC645CE7A5AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fate of potentially self-reactive T cells in neonatal mice: analysis of V beta 6+ T cells in Mlsa mice
Journal
Thymus
Author(s)
Schneider  R., Lees  R., Pedrazzini  T., Odermatt  B., Speiser  D. E., Zinkernagel  R. M., Hengartner  H., MacDonald  H. R.
ISSN
0165-6090 (Print)
Publication state
Published
Issued date
1989
Volume
13
Number
1-2
Pages
35-43
Notes
Journal Article
Research Support, Non-U.S. Gov't
Abstract
FACS analysis of either CD4 or CD8 depleted thymocytes revealed, that in adult Mlsa mice among CD4+ or CD8+ subpopulation of mature T cells V beta 6+ cells were absent. In contrast neonatal Mlsa mice had CD4+ V beta 6+ cells that rapidly decreased after day 4. On thymus cryosections of neonatal DBA/2 (Mlsa) mice V beta 6+ cells were found both in the cortex and the medulla of the thymus, in addition V beta 6+ cells were also detected in lymph nodes. After day 7-8 V beta 6+ cells disappeared from the medulla and the periphery. In the adult thymus only dull staining V beta 6+ cells were present in the cortex. Comparison of the fluorescence intensities of V beta 6 staining thymocytes from neonatally with Mlsa spleen cells tolerized mice with that of untreated BALB/c controls showed a significant decrease in T cell receptor density. Neonatal V beta 6+ T cells could be shown to be autoreactive against Mlsa, this reactivity declined at about the same time when the stimulatory capacity of Mlsa was established and could be first shown on day 4.
Keywords
Animals Animals, Newborn Antigens, CD4 Antigens, CD8 Antigens, Differentiation, T-Lymphocyte *Antigens, Surface Autoantigens Immune Tolerance Kinetics Mice Mice, Inbred Strains Minor Lymphocyte Stimulatory Antigens *Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell, alpha-beta T-Lymphocytes/*immunology Thymus Gland/cytology/immunology
Pubmed
Web of science
Create date
28/01/2008 11:32
Last modification date
20/08/2019 16:27
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