Genetic association analyses reveal a role for vitamin D insufficiency in hepatitis C virus-associated hepatocellular carcinoma development

Details

Serval ID
serval:BIB_FC6194654AED
Type
Inproceedings: an article in a conference proceedings.
Collection
Publications
Title
Genetic association analyses reveal a role for vitamin D insufficiency in hepatitis C virus-associated hepatocellular carcinoma development
Title of the conference
Annual Meeting of the Swiss Society of Gastroenterology, Swiss Society of Visceral Surgery, Swiss Association of the Study of the Liver and Swiss Society of Clinical Nutrition
Author(s)
Lange C.M., Miki D., Ochi H., Nischalke H.D., Bojunga J., Bibert S., Morikawa K., Gouttenoire J., Cerny A., Dufour J.F., Gorgievski-Hrisoho M., Heim M.H., Malinverni R., Müllhaupt B., Negro F., Semela D., Kutalik Z., Müller T., Spengler U., Berg T., Chayama K., Moradpour D., Bochud P.Y.
Organization
Congrès annuel de la SGG
Address
Interlaken, Switzerland, September 20-21, 2012
ISBN
1424-7860
ISSN-L
0036-7672
Publication state
Published
Issued date
2012
Volume
142
Series
Swiss Medical Weekly
Pages
4S
Language
english
Abstract
Background: V itamin D insufficiency has been associated with the
occurrence of various types of cancer, but causal relationships remain elusive.
Methods: Associations between t he r isk o f HCV-related HCC development
and CYP2R1 , GC, and DHCR7 genotypes, which are genetic determinants of
reduced 25-OH-vitamin D3 (25[OH]D3) serum levels, were determined.
Results: A t otal of 5604 HCV-infected patients, 1279 with a nd 4325 without
progression to HCC, w ere identified. The well-known association between
25(OH)D3 s erum levels and variations in CYP2R1 ( rs1993116, rs10741657),
GC ( rs2282679), a nd DHCR7 ( rs7944926, rs12785878) g enotypes was also
apparent in patients w ith chronic hepatitis C. The same genotypes of t hese
single nucleotide polymorphisms (SNPs), w hich are associated with reduced
25(OH)D3 s erum levels, were significantly associated with HCV-associated
HCC (P=0.07 [OR=1.13] for CYP2R1 , P=0.007 [OR=1.56] for GC, P=0.003
[OR=1.42] for DHCR7; ORs for risk genotypes). In contrast, no association
between t hese genetic variations and the o utcome of antiviral therapy with
pegylated interferon-α and ribavirin ( P>0.2 for e ach SNP) or liver fibrosis
progression rate (P>0.2 for each SNP) was observed, s uggesting a specific
influence o f the genetic d eterminants of 25(OH)D3 s erum levels o n
hepatocarcinogenesis.
Conclusions: Our data suggest a relatively weak but functionally relevant role
for vitamin D in the prevention of HCV-related HCC development. Controlled
clinical trials to assess the benefit of vitamin D supplementation in HCVinfected
patients with advanced liver fibrosis or cirrhosis are warranted.
Create date
14/02/2013 14:44
Last modification date
20/08/2019 17:27
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