Novel therapies for cutaneous T-cell lymphoma: what does the future hold?

Details

Serval ID
serval:BIB_FBE93840ED1D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Novel therapies for cutaneous T-cell lymphoma: what does the future hold?
Journal
Expert opinion on investigational drugs
Author(s)
Guenova E., Hoetzenecker W., Rozati S., Levesque M.P., Dummer R., Cozzio A.
ISSN
1744-7658 (Electronic)
ISSN-L
1354-3784
Publication state
Published
Issued date
04/2014
Peer-reviewed
Oui
Volume
23
Number
4
Pages
457-467
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Cutaneous T-cell lymphomas (CTCLs) represent a group of extranodal non-Hodgkin lymphomas, of which mycosis fungoides (MF) is the most frequent. Standard therapeutic approaches are well established and often achieve stable disease. However, cure for MF is rare and thus novel therapies are needed.
This review provides a discussion of the most promising new therapeutic approaches in the management of MF and other rare CTCLs. It includes targeted therapies with antibodies against surface molecules on malignant T cells (e.g., brentuximab), novel chemotherapeutic agents (e.g., pralatrexate), small-molecule compounds (e.g., panobinostat) and evidence of emerging targets in CTCLs (e.g., anti-IL-31). It also provides discussion of immune checkpoint inhibitors such as anti-PD1 that are worth considering in the treatment of leukaemic CTCL variants. Finally, it gives a brief overview of the possible use of stem-cell transplantation.
There is no doubt that progress has been made in the treatment of CTCLs with new, innovative and promising therapies approaching. However, there is still an urgent need to identify and test additional targets in well-designed clinical trials.
Keywords
Animals, Antineoplastic Agents/therapeutic use, Humans, Lymphoma, T-Cell, Cutaneous/drug therapy, Skin Neoplasms/drug therapy
Pubmed
Web of science
Create date
27/08/2020 13:59
Last modification date
02/09/2020 5:26
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