Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan.
Details
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_FBC212F1326C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan.
Journal
New microbes and new infections
ISSN
2052-2975 (Print)
ISSN-L
2052-2975
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
32
Pages
100605
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Extended-spectrum β-lactamases, carbapenemases, 16S rRNA methylases conferring pan-drug aminoglycoside resistance and colistin resistance were investigated among Gram-negative bacteria recovered from clinical samples (infections) from 200 individuals hospitalized at the Khyber Teaching Hospital of Peshawar, north Pakistan, from December 2017 to March 2018. Out of 65 isolates recovered, 19% were carbapenem resistant and 16% carried a bla <sub>NDM-1</sub> gene, confirming the widespread distribution of NDM producers in this country. The association of the NDM carbapenem-resistance determinant, together with the extended-spectrum β-lactamase CTX-M-15 and 16S rRNA methylases, was frequent, explaining the multidrug-resistance pattern observed. All isolates remained susceptible to colistin.
Keywords
Ion Channels/physiology, Microcomputers, Software, 16S rRNA methylases, Carbapenemases, Extended spectrum β-lactamase, Pakistan, ST 215, ST 231
Pubmed
Web of science
Open Access
Yes
Create date
14/11/2019 10:48
Last modification date
23/04/2024 6:18
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