Correlation study between osteoporosis and hematopoiesis in the context of adjuvant chemotherapy for breast cancer.

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License: CC BY 4.0
Serval ID
serval:BIB_FBB20C5D91BD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Correlation study between osteoporosis and hematopoiesis in the context of adjuvant chemotherapy for breast cancer.
Journal
Annals of hematology
Author(s)
Schyrr F., Wolfer A., Pasquier J., Nicoulaz A.L., Lamy O., Naveiras O.
ISSN
1432-0584 (Electronic)
ISSN-L
0939-5555
Publication state
Published
Issued date
02/2018
Peer-reviewed
Oui
Volume
97
Number
2
Pages
309-317
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
This retrospective study attempts to establish if a correlation exists between osteoporosis and hematopoiesis before and after adjuvant chemotherapy in the context of non-metastatic breast cancer. Osteoporosis is interpreted both as a direct marker of osteoblastic decline and as an indirect marker of increased bone marrow adiposity within the hematopoietic microenvironment. Patients from the "Centre du Sein" at CHUV (Centre Hospitalier Universitaire Vaudois) undergoing adjuvant chemotherapy were included in this study. Evolution of blood counts was studied in correlation with the osteoporosis status. Toxicity of chemotherapy was coded according to published probability of febrile neutropenia. One hundred forty-three women were included: mean age 52.1 ± 12.5 years, mean BMI (body mass index) 24.4 ± 4.1. BMD (bone mineral density) scored osteoporotic in 32% and osteopenic in 45%. Prior to chemotherapy, BMD was positively correlated with neutrophil (p < 0.001) and thrombocyte (p = 0.01) count; TBS (trabecular bone score) was not correlated with blood count. After the first cycle of chemotherapy, an increase of one point in TBS correlated with a decrease of 57% on the time to reach leucocyte nadir (p = 0.004). There was a positive correlation between BMD and risk of infection (p < 0.001). Our data demonstrates an association between osteoporosis and lower blood counts in a younger cohort than previously published, extending it for the first time to neutrophil counts in females. Our results suggest that the healthier the bone, the earlier the lowest leucocyte count value, prompting further research on this area.

Keywords
Absorptiometry, Photon, Adipocytes/drug effects, Adipocytes/immunology, Adipocytes/pathology, Adult, Aged, Antineoplastic Agents/administration & dosage, Antineoplastic Agents/adverse effects, Blood Platelets/drug effects, Blood Platelets/immunology, Blood Platelets/pathology, Body Mass Index, Bone Density/drug effects, Bone Density/immunology, Bone Diseases, Metabolic/complications, Bone Diseases, Metabolic/diagnostic imaging, Bone Diseases, Metabolic/drug therapy, Bone Diseases, Metabolic/immunology, Bone Marrow Cells/drug effects, Bone Marrow Cells/immunology, Bone Marrow Cells/pathology, Breast Neoplasms/complications, Breast Neoplasms/diagnostic imaging, Breast Neoplasms/drug therapy, Breast Neoplasms/immunology, Cell Count, Chemotherapy, Adjuvant, Female, Hematopoiesis/drug effects, Hematopoiesis/immunology, Humans, Lumbar Vertebrae/diagnostic imaging, Lumbar Vertebrae/drug effects, Lumbar Vertebrae/immunology, Lumbar Vertebrae/pathology, Middle Aged, Neutropenia/chemically induced, Neutropenia/diagnostic imaging, Neutropenia/immunology, Neutropenia/pathology, Neutrophils/drug effects, Neutrophils/immunology, Neutrophils/pathology, Osteoblasts/drug effects, Osteoblasts/immunology, Osteoblasts/pathology, Osteoporosis/complications, Osteoporosis/diagnostic imaging, Osteoporosis/drug therapy, Osteoporosis/immunology, Retrospective Studies, Anemia, Bone marrow adipocytes, Bone marrow microenvironment, Breast cancer, Chemotherapy, Febrile neutropenia, Graded toxicity of chemotherapy, Hematopoiesis, Neutrophil, Osteoblast, Osteoporosis, Platelet, Stress hematopoiesis, T-score, TBS, Trabecular bone score
Pubmed
Web of science
Open Access
Yes
Create date
30/11/2017 20:24
Last modification date
20/08/2019 17:26
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