The role of COX-2 in rectal cancer treated with preoperative radiotherapy.

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Serval ID
serval:BIB_FB1A4B25BDF0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The role of COX-2 in rectal cancer treated with preoperative radiotherapy.
Journal
Virchows Archiv
Author(s)
Bouzourene H., Yan P., Sandmeier D., Zouhair A., Matter M., Vuilleumier H., Coucke P.
ISSN
0945-6317
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
452
Number
5
Pages
499-505
Language
english
Notes
Publication types: Journal Article ;
Abstract
Radiotherapy is one of the principal modalities of rectal cancer treatment, and the ability to predict radio resistance could potentially improve survival through a targeted treatment approach. Cyclooxygenase-2 (COX-2) may protect against damage by irradiation that would justify the use of COX-2 inhibitors. The purpose of this study was to investigate the potential role of COX-2 in tumor response and outcome of patients with rectal cancer treated preoperatively with radiotherapy. Using immunohistochemistry, we examined COX-2 expression in 88 surgical specimens of rectal cancer treated preoperatively and in 26 pretherapeutic biopsies. We tested whether COX-2 expression was correlated with clinico-pathologic parameters and with survival and local recurrence. COX-2 was expressed in 50% of the pretherapeutic tumor biopsies and in 88.6% of post-irradiated surgical samples. COX-2 expression was correlated only with enhanced tumor inflammation (p = 0.03) and with tumor volume exceeding 30 cc (p = 0.05). COX-2 was not significantly correlated with patient survival, but none of the patients with COX-2 negative tumors did recur locally, whereas 80% of patients with local recurrences have COX-2 positive tumors. We conclude that COX-2 expression is overexpressed in the majority of rectal cancers treated with radiotherapy and likely plays a role in local relapse.
Keywords
Adenocarcinoma, Adult, Aged, Aged, 80 and over, Cyclooxygenase 2, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Preoperative Care, Prognosis, Rectal Neoplasms, Retrospective Studies, Survival Analysis, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
22/05/2008 12:57
Last modification date
01/10/2019 7:20
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