Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment.

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State: Public
Version: author
Serval ID
serval:BIB_FAD2136DA3E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment.
Journal
Neurology
Author(s)
Scheef L., Spottke A., Daerr M., Joe A., Striepens N., Kölsch H., Popp J., Daamen M., Gorris D., Heneka M.T., Boecker H., Biersack H.J., Maier W., Schild H.H., Wagner M., Jessen F.
ISSN
1526-632X (Electronic)
ISSN-L
0028-3878
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
79
Number
13
Pages
1332-1339
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
OBJECTIVE: To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance and to investigate the longitudinal cognitive course in these subjects.
METHOD: [¹⁸F]fluoro-2-deoxyglucose PET (FDG-PET) and structural MRI were acquired in 31 subjects with SMI and 56 controls. Cognitive follow-up testing was performed (average follow-up time: 35 months). Differences in baseline brain imaging data and in memory decline were assessed between both groups. Associations of memory decline with brain imaging data were tested.
RESULTS: The SMI group showed hypometabolism in the right precuneus and hypermetabolism in the right medial temporal lobe. Gray matter volume was reduced in the right hippocampus in the SMI group. At follow-up, subjects with SMI showed a poorer performance than controls on measures of episodic memory. Longitudinal memory decline in the SMI group was associated with reduced glucose metabolism in the right precuneus at baseline.
CONCLUSION: The cross-sectional difference in 2 independent neuroimaging modalities indicates early AD pathology in SMI. The poorer memory performance at follow-up and the association of reduced longitudinal memory performance with hypometabolism in the precuneus at baseline support the concept of SMI as the earliest manifestation of AD.
Keywords
Aged, Brain/metabolism, Brain/pathology, Female, Fluorodeoxyglucose F18/diagnostic use, Follow-Up Studies, Glucose/metabolism, Humans, Magnetic Resonance Imaging/methods, Male, Memory Disorders/diagnosis, Memory, Episodic, Neuropsychological Tests, Positron-Emission Tomography/methods
Pubmed
Web of science
Create date
24/08/2012 9:46
Last modification date
20/08/2019 16:26
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