Distribution properties of polymononucleotide repeats in molluscan genomes.

Details

Serval ID
serval:BIB_FAC358493C7B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Distribution properties of polymononucleotide repeats in molluscan genomes.
Journal
Journal of Heredity
Author(s)
Pérez M., Cruz F., Presa P.
ISSN
0022-1503
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
96
Number
1
Pages
40-51
Language
english
Abstract
A total of 635 DNA sequences from 35 species of mollusks were used as taxonomic support to investigate several distribution features of polymononucleotides in genomic regions of different functionality. We show that all polymononucleotide types in mollusks fit to expectations in exons but not in nonexonic regions, in agreement with a leading role of negative selection on expansions/contractions of transcription-linked poly-(A/T) repeats. The fit of all repeat length types to an exponential decay precludes the existence of a threshold size for replication slippage, a popular but unsatisfactorily explained concept in mutation models for single repeats. The genomic density of poly-(A/T) repeats is not correlated with the DNA content of species, suggesting that the differential density of repeats between species could be better explained by the species-specific performance of its repair mechanisms. This research allows a better understanding of the distribution patterns of single repeats in eukaryotes.
Keywords
Animals, Computational Biology/methods, DNA/genetics, DNA, Intergenic/genetics, Exons/genetics, Genome, Introns/genetics, Microsatellite Repeats, Mollusca/genetics, Poly A/analysis, Poly C/analysis, Poly G/analysis, Poly T/analysis, Untranslated Regions/genetics
Pubmed
Web of science
Open Access
Yes
Create date
11/03/2008 7:37
Last modification date
20/08/2019 16:26
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