Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature.

Details

Serval ID
serval:BIB_FABB87E80824
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature.
Journal
Endocrine Pathology
Author(s)
La Rosa S., Bernasconi B., Micello D., Finzi G., Capella C.
ISSN
1046-3976 (Print)
ISSN-L
1046-3976
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
20
Number
1
Pages
24-34
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In addition, we have reviewed the literature and compared the published clinicopathological data with our morphological and genetic results. The tumor arose within the kidney parenchyma and showed the typical histological features of a pure small cell PDNEC. Fluorescence in situ hybridization study demonstrated a complex chromosomal assessment indicative of a high degree of chromosome instability with gain of multiple chromosomes, loss of p53, and amplification of myc gene. These results suggest that renal PDNEC has a different genetic background to renal clear cell carcinoma, mainly characterized by the loss of the short arm of chromosome 3. Conversely, genetic alterations seem to resemble those of type 2 papillary renal cell carcinoma. The review of the literature demonstrated that PDNECs are associated with poor prognosis and that parenchymal tumors show some differences from those arising in the pelvis, in that parenchymal tumors are purely neuroendocrine while pelvic tumors are mostly mixed neuroendocrine-exocrine neoplasms.
Keywords
Aged, 80 and over, Carcinoma, Neuroendocrine/genetics, Carcinoma, Neuroendocrine/metabolism, Carcinoma, Small Cell/genetics, Carcinoma, Small Cell/metabolism, Cytogenetics, Gene Amplification, Genes, myc, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Kidney Neoplasms/genetics, Kidney Neoplasms/metabolism, Male, Microscopy, Electron, Transmission, Tumor Suppressor Protein p53/genetics
Pubmed
Web of science
Create date
06/09/2016 14:00
Last modification date
20/08/2019 16:26
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