Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity.
Details
Serval ID
serval:BIB_FAB8273FB0C1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity.
Journal
Nature medicine
ISSN
1546-170X (Electronic)
ISSN-L
1078-8956
Publication state
Published
Issued date
02/2020
Peer-reviewed
Oui
Volume
26
Number
2
Pages
222-227
Language
english
Notes
Publication types: Clinical Trial, Phase I ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Combination antiretroviral therapy (ART) is highly effective in controlling human immunodeficiency virus (HIV)-1 but requires lifelong medication due to the existence of a latent viral reservoir <sup>1,2</sup> . Potent broadly neutralizing antibodies (bNAbs) represent a potential alternative or adjuvant to ART. In addition to suppressing viremia, bNAbs may have T cell immunomodulatory effects as seen for other forms of immunotherapy <sup>3</sup> . However, this has not been established in individuals who are infected with HIV-1. Here, we document increased HIV-1 Gag-specific CD8 <sup>+</sup> T cell responses in the peripheral blood of all nine study participants who were infected with HIV-1 with suppressed blood viremia, while receiving bNAb therapy during ART interruption <sup>4</sup> . Increased CD4 <sup>+</sup> T cell responses were detected in eight individuals. The increased T cell responses were due both to newly detectable reactivity to HIV-1 Gag epitopes and the expansion of pre-existing measurable responses. These data demonstrate that bNAb therapy during ART interruption is associated with enhanced HIV-1-specific T cell responses. Whether these augmented T cell responses can contribute to bNAb-mediated viral control remains to be determined.
Keywords
Adult, Antibodies, Neutralizing/immunology, CD4-Positive T-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/virology, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/virology, Epitopes/immunology, Female, Gene Products, gag/metabolism, HIV Antibodies/immunology, HIV Infections/immunology, HIV Infections/therapy, HIV Infections/virology, HIV-1, Humans, Immune System, Immunotherapy/methods, Interferon-gamma/immunology, Male, Middle Aged, T-Lymphocytes/immunology, T-Lymphocytes/virology, Viremia
Pubmed
Web of science
Publisher's website
Open Access
Yes
Create date
09/05/2023 12:59
Last modification date
29/11/2024 17:17