Primary pituitary lymphoma: an update of the literature.

Details

Serval ID
serval:BIB_FA653FDEE846
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Primary pituitary lymphoma: an update of the literature.
Journal
Journal of neuro-oncology
Author(s)
Tarabay A., Cossu G. (co-first), Berhouma M., Levivier M., Daniel R.T., Messerer M.
ISSN
1573-7373 (Electronic)
ISSN-L
0167-594X
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
130
Number
3
Pages
383-395
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Primary intracranial lymphomas (Weller et al. in Neuro Oncol 14(12):1481-1484, 2012) are an emerging disease and an isolated localization in the pituitary gland i.e. primary pituitary lymphoma (PPL) represents a rare condition. We present an update of the most recent evidence for PPL through a systematic review of the literature. A systematic literature review was conducted using PubMed database up to October 2015. The population was defined as immunocompetent patients with a pathologically confirmed diagnosis of PPL. Patients' characteristics, clinical presentation, radiological features, pathology reports, adjuvant treatment and follow-up data were analyzed. We reported one case of PPL and included our data in this analysis. A total of 33 cases of PPL were identified, including ours. A slight not significant female prevalence was evident, with a mean age of 59 years at diagnosis. Visual troubles and headaches were the most common presenting symptoms. About 80 % of patients presented a cranial nerve (CN) deficit. The most frequently involved were the II and III CN. Anterior hypopituitarism was present in 70 % of cases and a diabetes insipidus in 36 % of cases. PPL was rarely limited to the sella and most often extended to the suprasellar and parasellar space. 70 % of cases underwent resection, 21 % a biopsy. A B-cell lymphoma was isolated in 82 % of cases, a T-cell lymphoma in 15 % and a NK/T cell lymphoma in one case. Overall mean survival rate was 14.4 months (95 % confidence interval 9.0-19.8 months) and there was no difference in terms of survival rates when patients were stratified according to the treatment they received. PPL is an emerging clinical entity. Literature data are too scarce to allow the definition of specific protocols of treatment and the management is based on the guidelines present for PCNSL. The role of surgery aiming at a complete resection of PPL should be reevaluated in wider studies including only this category of patients, to establish the real role of each therapeutic strategy.
Keywords
Central Nervous System Neoplasms/diagnosis, Central Nervous System Neoplasms/therapy, Humans, Lymphoma/diagnosis, Lymphoma/therapy, Pituitary Neoplasms/diagnosis, Pituitary Neoplasms/therapy, PubMed/statistics & numerical data, Chemotherapy, Endoscopic endonasal surgery, Primary central nervous system lymphoma, Primary pituitary lymphoma, Radiotherapy, Sellar mass, Trans-sphenoidal surgery
Pubmed
Web of science
Create date
12/09/2016 13:13
Last modification date
09/04/2020 6:21
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