Trials using a crossover design and ambulatory blood pressure recordings to determine the efficacy of antihypertensive agents in individual patients.

Details

Serval ID
serval:BIB_FA3DC999C7E8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Trials using a crossover design and ambulatory blood pressure recordings to determine the efficacy of antihypertensive agents in individual patients.
Journal
Journal of hypertension. Supplement
Author(s)
Waeber B., Burnier M., Nussberger J., Brunner H.R.
ISSN
0952-1178
Publication state
Published
Issued date
1990
Volume
8
Number
4
Pages
S37-41
Language
english
Abstract
The antihypertensive effects of the beta-blocking agent betaxolol and the calcium entry blocker verapamil were compared in a crossover single-blind trial. Seventeen patients with uncomplicated essential hypertension took either betaxolol or a slow-release formulation of verapamil for two consecutive 6-week periods. The sequence of treatment phases was randomly allocated and a 2-week washout period preceded each treatment. The antihypertensive effect of the test drugs was assessed both at the physician's office and during everyday activities using a portable blood pressure recorder. The crossover design of the trial made it possible to evaluate the antihypertensive efficacy of betaxolol and verapamil both in the group as a whole and in the individual patient. The individual patient response to one of these agents was not a reliable indicator of the same patient's response to the alternative agent. Betaxolol brought both office and ambulatory recorded blood pressures under control in a larger fraction of patients than verapamil, although the magnitude of the blood pressure fall in the responders was equal for each drug. These observations stress the need for an individualized approach to the evaluation of antihypertensive therapy. The present results also demonstrate that optimal antihypertensive therapy is still a matter of trial and error. The precise methodology that ought to characterize crossover trials may make it possible to improve the therapeutic approach to hypertensive patients.
Keywords
Ambulatory Care, Betaxolol, Blood Pressure, Delayed-Action Preparations, Drug Administration Schedule, Humans, Hypertension, Single-Blind Method, Verapamil
Pubmed
Web of science
Create date
25/01/2008 13:55
Last modification date
03/03/2018 22:55
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