Urinary low-molecular-weight protein excretion in pediatric idiopathic nephrotic syndrome.

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Serval ID
serval:BIB_FA297C824621
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Urinary low-molecular-weight protein excretion in pediatric idiopathic nephrotic syndrome.
Journal
Pediatric Nephrology
Author(s)
Chehade H., Parvex P., Poncet A., Werner D., Mosig D., Cachat F., Girardin E.
ISSN
1432-198X (Electronic)
ISSN-L
0931-041X
Publication state
Published
Issued date
2013
Volume
28
Number
12
Pages
2299-2306
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. pdf type: original article
Abstract
BACKGROUND: Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are the most common causes of idiopathic nephrotic syndrome (INS). We have evaluated the reliability of urinary neutrophil-gelatinase-associated lipocalin (uNGAL), urinary alpha1-microglobulin (uα1M) and urinary N-acetyl-beta-D-glucosaminidase (uβNAG) as markers for differentiating MCD from FSGS. We have also evaluated whether these proteins are associated to INS relapses or to glomerular filtration rate (GFR).
METHODS: The patient cohort comprised 35 children with MCD and nine with FSGS; 19 healthy age-matched children were included in the study as controls. Of the 35 patients, 28 were in remission (21 MCD, 7 FSGS) and 16 were in relapse (14 MCD, 2 FSGS). The prognostic accuracies of these proteins were assessed by receiver operating characteristic (ROC) curve analyses.
RESULTS: The level of uNGAL, indexed or not to urinary creatinine (uCreat), was significantly different between children with INS and healthy children (p = 0.02), between healthy children and those with FSGS (p = 0.007) and between children with MCD and those with FSGS (p = 0.01). It was not significantly correlated to proteinuria or GFR levels. The ROC curve analysis showed that a cut-off value of 17 ng/mg for the uNGAL/uCreat ratio could be used to distinguish MCD from FSGS with a sensitivity of 0.77 and specificity of 0.78. uβNAG was not significantly different in patients with MCD and those with FSGS (p = 0.86). Only uα1M, indexed or not to uCreat, was significantly (p < 0.001) higher for patients in relapse compared to those in remission.
CONCLUSIONS: Our results indicate that in our patient cohort uNGAL was a reliable biomarker for differentiating MCD from FSGS independently of proteinuria or GFR levels.
Pubmed
Web of science
Open Access
Yes
Create date
01/12/2013 16:14
Last modification date
01/10/2019 7:20
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