Peripheral nerve injury induces a transitory microglial reaction in the rat infralimbic cortex.

Details

Serval ID
serval:BIB_FA15C1B73D08
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Peripheral nerve injury induces a transitory microglial reaction in the rat infralimbic cortex.
Journal
Neuroscience letters
Author(s)
Chu Sin Chung P., Panigada T., Cardis R., Decosterd I., Gosselin R.D.
ISSN
1872-7972 (Electronic)
ISSN-L
0304-3940
Publication state
Published
Issued date
10/08/2017
Peer-reviewed
Oui
Volume
655
Pages
14-20
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Undeniable evidence shows that microglia in the spinal cord undergo marked reactions following peripheral injuries. However, only rare studies have investigated the possible short and long term microglial reaction in brain regions following peripheral nerve injury and its interspecies specificities. In the present study we examined microglia in subdivisions of the prefrontal cortex in mice and rats, 7days and 42days after spared nerve injury (SNI) of the sciatic nerve. We show that a bilateral increase of microglial density takes place in the infralimbic cortex in rats 7days post-injury (sham vs. SNI, n=5: ipsilateral 35.4% increase of the median, p=0.0317; contralateral 24.9% increase of the median, p=0.0079), without any detectable change in the other investigated regions, namely the anterior cingulate, prelimbic and agranular insular cortices. In mice, no observable difference could be found in any region at both time points, neither using Iba-1 immunostaining nor with CX3CR1-eGFP animals. Our results indicate that a transitory, species-specific and highly regionalized microglial reaction takes place in the prefrontal cortex following peripheral nerve injury.

Keywords
Animals, Mice, Inbred C57BL, Mice, Transgenic, Microglia/pathology, Peripheral Nerve Injuries/pathology, Prefrontal Cortex/pathology, Rats, Sprague-Dawley, Sciatic Nerve/injuries, Species Specificity, CX3CR1-eGFP, Iba1, Infralimbic, Microglia, Nerve injury, Prefrontal cortex
Pubmed
Web of science
Create date
10/08/2017 10:04
Last modification date
20/08/2019 16:25
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