Intrathecal sufentanil-morphine shortens the duration of intubation and improves analgesia in fast-track cardiac surgery
Details
Serval ID
serval:BIB_F98A76EEC174
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intrathecal sufentanil-morphine shortens the duration of intubation and improves analgesia in fast-track cardiac surgery
Journal
Canadian Journal of Anaesthesia
ISSN
0832-610X (Print)
Publication state
Published
Issued date
09/2002
Volume
49
Number
7
Pages
711-7
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Aug-Sep
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Aug-Sep
Abstract
PURPOSE: To compare the effect of combined intrathecal morphine and sufentanil with low-dose iv sufentanil during propofol anesthesia for fast-track cardiac surgery. METHODS: Twenty-four consecutive patients with normal cardiopulmonary function who were scheduled for elective cardiac surgery were randomized to receive either a continuous iv infusion of sufentanil 0.9 to 1.8 microg x kg(-1) x min(-1) (13 patients), or a single lumbar intrathecal dose of sufentanil 50 micro g and morphine 500 micro g (11 patients). We prospectively studied perioperative analgesia, time to extubation and early postoperative maximal inspiratory capacity in the two groups. In the intensive care unit, the medical and nursing staff were blinded to the analgesic technique. RESULTS: Intrathecal sufentanil morphine allowed a shorter duration of intubation (104 +/- 56.5 min vs 213 +/- 104 min; P = 0.01), reduced the need for postoperative analgesia with nicomorphine (equipotent to morphine) (0.7 +/- 0.4 mg x hr(-1) vs 1.2 +/- 0.4 mg x hr(-1); P = 0.008) and improved postoperative maximal inspiratory capacity (53.4 +/- 16.1 vs 38.4 +/- 12.5% of the norm; P = 0.05). CONCLUSION: In low-risk patients undergoing coronary artery bypass graft or valve surgery, combined intrathecal sufentanil and morphine with a target-controlled infusion of propofol satisfies the goals of fast-track cardiac surgery.
Keywords
Adult
Aged
Analgesics, Opioid/*administration & dosage/therapeutic use
*Anesthetics, Combined
*Cardiac Surgical Procedures
Female
Heart Diseases/surgery
Humans
Injections, Spinal
Intraoperative Care
Intubation, Intratracheal/*methods
Male
Middle Aged
Morphine/*administration & dosage/therapeutic use
Pain, Postoperative/*prevention & control
Propofol/administration & dosage
Prospective Studies
Sufentanil/*administration & dosage/therapeutic use
Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:43
Last modification date
20/08/2019 17:25