Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

Details

Serval ID
serval:BIB_F93AC620BB91
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Journal
Embo Reports
Author(s)
Lopez-Mejia I.C., de Toledo M., Chavey C., Lapasset L., Cavelier P., Lopez-Herrera C., Chebli K., Fort P., Beranger G., Fajas L., Amri E.Z., Casas F., Tazi J.
ISSN
1469-3178 (Electronic)
ISSN-L
1469-221X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
15
Number
5
Pages
529-539
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish PDF : Scientific Report
Abstract
Alternative RNA processing of LMNA pre-mRNA produces three main protein isoforms, that is, lamin A, progerin, and lamin C. De novo mutations that favor the expression of progerin over lamin A lead to Hutchinson-Gilford progeria syndrome (HGPS), providing support for the involvement of LMNA processing in pathological aging. Lamin C expression is mutually exclusive with the splicing of lamin A and progerin isoforms and occurs by alternative polyadenylation. Here, we investigate the function of lamin C in aging and metabolism using mice that express only this isoform. Intriguingly, these mice live longer, have decreased energy metabolism, increased weight gain, and reduced respiration. In contrast, progerin-expressing mice show increased energy metabolism and are lipodystrophic. Increased mitochondrial biogenesis is found in adipose tissue from HGPS-like mice, whereas lamin C-only mice have fewer mitochondria. Consistently, transcriptome analyses of adipose tissues from HGPS and lamin C-only mice reveal inversely correlated expression of key regulators of energy expenditure, including Pgc1a and Sfrp5. Our results demonstrate that LMNA encodes functionally distinct isoforms that have opposing effects on energy metabolism and lifespan in mammals.
Pubmed
Web of science
Open Access
Yes
Create date
20/06/2014 17:32
Last modification date
20/08/2019 16:25
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