Metadifferentiation of iris nevi after iridectomy: a clinicopathological small case series

Details

Serval ID
serval:BIB_F8FFE3382157
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Title
Metadifferentiation of iris nevi after iridectomy: a clinicopathological small case series
Title of the conference
Acta Ophthalmologica
Author(s)
Schalenbourg A., Roberti P., Zografos L.
Organization
European Association for Vision and Eye Research
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
88
Language
english
Abstract
Abstract
Purpose Iridectomy of suspicious pigmented tumors provides the presumed advantage of both a histopathological diagnosis and treatment of the lesion. We present 2 patients that developed an iris melanoma with extrascleral extension at the site of their iridectomy of a histopathologically proven nevus, 46 and 2.5 years later.
Methods Retrospective, clinicopathological small case series of 2 patients.
Results Two patients underwent iridectomy for a suspicious tumor, the first in 1963 and the second in 2006. Pathological diagnosis was a benign and a borderline nevus respectively. In 2009, both patients presented with a recurrent melanocytic iridociliary tumor with an extrascleral extension adjacent to the surgical scar. Pathological examination confirmed melanoma. Consequently, the two patients underwent proton beam therapy of the whole anterior segment, with limbus deposition and reposition.
Conclusion Iridectomy of a histopathologically proven nevus doesn't exclude the possibility of a metadifferentiation of remaining nevus cells into melanoma, even after 46 years. Additionally, treatment in case of a recurrence is more complicated than a primary radiotherapy of the unbiopsied iris tumor, with clinical proof of growth, would have been.
Create date
04/02/2011 12:24
Last modification date
20/08/2019 17:24
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