Evaluation of antiarrhythmic drug efficacy in patients with an ICD: unlimited potential or replete with complexity and problems?

Details

Serval ID
serval:BIB_F8B8AF8FA62E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Evaluation of antiarrhythmic drug efficacy in patients with an ICD: unlimited potential or replete with complexity and problems?
Journal
Journal of Cardiovascular Electrophysiology
Author(s)
Pratt  C. M., Camm  A. J., Bigger, J. T., Jr. , Breithardt  G., Campbell  R. W., Epstein  A. E., Kappenberger  L. J., Kuck  K. H., Pocock  S., Saksena  S., Waldo  A. L.
ISSN
1045-3873 (Print)
Publication state
Published
Issued date
11/1999
Volume
10
Number
11
Pages
1534-49
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Nov
Abstract
There are a number of novel ways in which implantable cardioverter defibrillator (ICD) endpoints can be used in clinical trials to evaluate antiarrhythmic drugs. The advances in ICD technology (storage, retrieval, and accurate interpretation of ICD electrograms) expand the potential to include the use of an ICD endpoint as a clinical surrogate for sudden death. The ICD also provides the necessary safety net to test new drugs. The frequent need for antiarrhythmic drugs in patients already fitted with an ICD (e.g., for atrial fibrillation) necessitates knowledge of the drugs' effect on defibrillator threshold. There are interpretative problems and challenges associated with all types of ICD trials. A particular difficult issue is the degree to which the results of data on antiarrhythmic drug efficacy and safety acquired in the context of an ICD endpoint trial might be extrapolated to patient populations in which the device is not used. These and other challenging issues are discussed, with the goal of enhancing the design and interpretation of clinical trials featuring ICD endpoints.
Keywords
Anti-Arrhythmia Agents/*therapeutic use Clinical Trials *Defibrillators, Implantable Drug Evaluation Humans Research Design
Pubmed
Web of science
Create date
15/02/2008 11:29
Last modification date
20/08/2019 16:24
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