Biomarkers of vulnerable plaque: the missing link with ischemia.

Details

Serval ID
serval:BIB_F85E8178A00A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Biomarkers of vulnerable plaque: the missing link with ischemia.
Journal
Biomarkers In Medicine
Author(s)
Muller O., Barbato E., De Bruyne B., Bartunek J.
ISSN
1752-0371 (Electronic)
ISSN-L
1752-0363
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
4
Number
3
Pages
375-383
Language
english
Abstract
The initial evaluation of chest pain in the emergency department is based on the patient's clinical history, changes in the ECG and necrosis biomarkers. Although management of patients with ST-elevation myocardial infarction or non-ST-elevation myocardial infarction with positive markers of myocardial damage is well defined, exclusion of coronary artery disease or myocardial ischemia in the remaining patients is more challenging. This group represents the majority of patients admitted for chest pain syndromes and that have a substantial risk of an adverse outcome. Given that troponin, as a marker of myocardial damage, detects terminal events in the cascade of acute coronary syndrome, there is a need to search for biomarkers that are able to identify patients at high risk, allowing rapid, bedside stratification. Data suggest that clinical events are prone to occur more frequently in patients with coronary artery stenosis associated with myocardial ischemia. Accordingly, identification of systemic biomarkers of ischemia could facilitate identification of high-risk patients with a high burden of coronary atherosclerosis and plaque rupture. We describe six biomarkers that have been linked to myocardial ischemia. Until now, these biomarkers of ischemia are relevant in order to exclude ischemic heart disease (high negative predictive value) but still lack specificity. Future prospective studies should be performed in larger and more diverse sets of patients presenting with ischemia, and in a complementary fashion in order to provide valuable tools for clinical decision making.
Keywords
Albumins/metabolism, Biological Markers/blood, Biological Markers/metabolism, Choline/blood, Coronary Artery Disease/diagnosis, Cystatin C/metabolism, Fatty Acids, Nonesterified/blood, Humans, Myocardial Infarction/diagnosis, Myocardial Ischemia/diagnosis, Myocardial Ischemia/metabolism, Natriuretic Peptide, Brain/metabolism, Toll-Like Receptors/metabolism, Troponin/blood
Pubmed
Web of science
Create date
16/02/2015 17:59
Last modification date
20/08/2019 16:24
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