The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer.

Details

Serval ID
serval:BIB_F80CD35B4D7C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer.
Journal
Cancers
Author(s)
Ziegler D.V., Huber K., Fajas L.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
29/12/2021
Peer-reviewed
Oui
Volume
14
Number
1
Pages
153
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
In the past decade, cell cycle regulators have extended their canonical role in cell cycle progression to the regulation of various cellular processes, including cellular metabolism. The regulation of metabolism is intimately connected with the function of autophagy, a catabolic process that promotes the efficient recycling of endogenous components from both extrinsic stress, e.g., nutrient deprivation, and intrinsic sub-lethal damage. Mediating cellular homeostasis and cytoprotection, autophagy is found to be dysregulated in numerous pathophysiological contexts, such as cancer. As an adaptative advantage, the upregulation of autophagy allows tumor cells to integrate stress signals, escaping multiple cell death mechanisms. Nevertheless, the precise role of autophagy during tumor development and progression remains highly context-dependent. Recently, multiple articles has suggested the importance of various cell cycle regulators in the modulation of autophagic processes. Here, we review the current clues indicating that cell-cycle regulators, including cyclin-dependent kinase inhibitors (CKIs), cyclin-dependent kinases (CDKs), and E2F transcription factors, are intrinsically linked to the regulation of autophagy. As an increasing number of studies highlight the importance of autophagy in cancer progression, we finally evoke new perspectives in therapeutic avenues that may include both cell cycle inhibitors and autophagy modulators to synergize antitumor efficacy.
Keywords
CDKs, CKI, E2F, autophagy, cancer, cell cycle regulators
Pubmed
Web of science
Open Access
Yes
Create date
17/01/2022 10:56
Last modification date
05/02/2022 7:32
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